Publications

Publications 2022

Arous D, Schrunner S, Hansson I, Edin NFJ, Malinen E (2022)
Principal component-based image segmentation: a new approach to outline in vitro cell colonies
Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, Online ahead of print, 1-13
DOI 10.1080/21681163.2022.2035822, PublikaID 404

Bahadoer RR, Bastiaannet E, Peeters KCMJ, van Eycken E, Verbeeck J, Guren MG, Kørner H, Martling A, Johansson R, van de Velde CJH, Dekker JWT (2022)
The survival gap between young and older patients after surgical resection for colorectal cancer remains largely based on early mortality: A EURECCA comparison of four European countries
J Geriatr Oncol, 13 (6), 803-812
DOI 10.1016/j.jgo.2022.04.011, PubMed 35527207

Bay LTE, Syljuåsen RG, Landsverk HB (2022)
A novel, rapid and sensitive flow cytometry method reveals degradation of promoter proximal paused RNAPII in the presence and absence of UV
Nucleic Acids Res (in press)
DOI 10.1093/nar/gkac434, PubMed 35641102

Berg J, Halvorsen AR, Bengtson MB, Lindberg M, Halvorsen B, Aukrust P, Helland Å, Ueland T (2022)
Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer
Front Immunol, 13, 875152
DOI 10.3389/fimmu.2022.875152, PubMed 35911763

Dijkstra EA, Hospers GAP, Kranenbarg EM, Fleer J, Roodvoets AGH, Bahadoer RR, Guren MG, Tjalma JJJ, Putter H, Crolla RMPH, Hendriks MP, Capdevila J, Radu C, van de Velde CJH, Nilsson PJ, Glimelius B, van Etten B, Marijnen CAM (2022)
Quality of life and late toxicity after short-course radiotherapy followed by chemotherapy or chemoradiotherapy for locally advanced rectal cancer - The RAPIDO trial
Radiother Oncol, 171, 69-76
DOI 10.1016/j.radonc.2022.04.013, PubMed 35447283

Eide IJZ, Stensgaard S, Helland Å, Ekman S, Mellemgaard A, Hansen KH, Cicenas S, Koivunen J, Grønberg BH, Sørensen BS, Brustugun OT (2022)
Osimertinib in non-small cell lung cancer with uncommon EGFR-mutations: a post-hoc subgroup analysis with pooled data from two phase II clinical trials
Transl Lung Cancer Res, 11 (6), 953-963
DOI 10.21037/tlcr-21-995, PubMed 35832438

Ellingsen EB, Aamdal E, Guren T, Lilleby W, Brunsvig PF, Mangsbo SM, Aamdal S, Hovig E, Mensali N, Gaudernack G, Inderberg EM (2022)
Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
J Immunother Cancer, 10 (5)
DOI 10.1136/jitc-2021-004345, PubMed 35613827

Evensen ME, Furre T, Malinen E, Løndalen AM, Dale E (2022)
Mucosa-sparing dose painting of head and neck cancer
Acta Oncol, 61 (2), 141-145
DOI 10.1080/0284186X.2021.2022200, PubMed 34991431

Falk P, Severin M, Berglund Å, Guren MG, Hofsli E, Österlund P, Tandberg A, Eberhard J, Sorbye H (2022)
Sex hormones and sperm parameters after adjuvant oxaliplatin-based treatment for colorectal cancer
Cancer Treat Res Commun, 31, 100517
DOI 10.1016/j.ctarc.2022.100517, PubMed 35114500

Franco P, Segelov E, Johnsson A, Riechelmann R, Guren MG, Das P, Rao S, Arnold D, Spindler KG, Deutsch E, Krengli M, Tombolini V, Sebag-Montefiore D, De Felice F (2022)
A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer
Cancers (Basel), 14 (7)
DOI 10.3390/cancers14071697, PubMed 35406469

Fuster-Garcia E, Thokle Hovden I, Fløgstad Svensson S, Larsson C, Vardal J, Bjørnerud A, Emblem KE (2022)
Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival
Cancers (Basel), 14 (7)
DOI 10.3390/cancers14071725, PubMed 35406497

Gongora M, Stranne J, Johansson E, Bottai M, Thellenberg Karlsson C, Brasso K, Hansen S, Jakobsen H, Jäderling F, Lindberg H, Lilleby W, Meidahl Petersen P, Mirtti T, Olsson M, Rannikko A, Andreas Røder M, Henrik Vincent P, Akre O (2022)
Characteristics of Patients in SPCG-15-A Randomized Trial Comparing Radical Prostatectomy with Primary Radiotherapy plus Androgen Deprivation Therapy in Men with Locally Advanced Prostate Cancer
Eur Urol Open Sci, 41, 63-73
DOI 10.1016/j.euros.2022.04.013, PubMed 35813256

Hanson I, Pitman KE, Altanerova U, Altaner Č, Malinen E, Edin NFJ (2022)
Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding
Int J Mol Sci, 23 (15)
DOI 10.3390/ijms23158147, PubMed 35897723

Harkos C, Svensson SF, Emblem KE, Stylianopoulos T (2022)
Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics
Cancers (Basel), 14 (4)
DOI 10.3390/cancers14040884, PubMed 35205632

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045

Ji X, Lin L, Fan J, Li Y, Wei Y, Shen S, Su L, Shafer A, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Zhang R, Chen F, Christiani DC (2022)
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC
Mol Oncol, 16 (3), 717-731
DOI 10.1002/1878-0261.13167, PubMed 34932879

Khadse A, Haakensen VD, Silwal-Pandit L, Hamfjord J, Micke P, Botling J, Brustugun OT, Lingjærde OC, Helland Å, Kure EH (2022)
Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma
Front Oncol, 12, 873532
DOI 10.3389/fonc.2022.873532, PubMed 35574381

Kvammen JA, Stensvold E, Godang K, Bollerslev J, Myklebust TÅ, Brandal P, Henriksen C, Bechensteen AG (2022)
Bone mineral density and nutrition in long-term survivors of childhood brain tumors
Clin Nutr ESPEN, 50, 162-169
DOI 10.1016/j.clnesp.2022.05.025, PubMed 35871919

Kørner H, Guren MG, Larsen IK, Haugen DF, Søreide K, Kørner LR, Søreide JA (2022)
Characteristics and fate of patients with rectal cancer not entering a curative-intent treatment pathway: A complete nationwide registry cohort of 3,304 patients
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2022.04.013, PubMed 35527055

Langen Stokmo H, Aly M, Bowitz Lothe IM, Borja AJ, Mehdizadeh Seraj S, Ghorpade R, Miao X, Hjortland GO, Malinen E, Sorbye H, Werner TJ, Alavi A, Revheim ME (2022)
Volumetric parameters from [¹⁸ F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms
J Neuroendocrinol, 34 (7), e13170
DOI 10.1111/jne.13170, PubMed 35729738

Lindegaard JC, Petric P, Schmid MP, Nesvacil N, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Kirchheiner K, Spampinato S, Jürgenliemk-Schulz I, Tanderup K, Kirisits C et al. (2022)
Prognostic Implications of Uterine Cervical Cancer Regression During Chemoradiation Evaluated by the T-Score in the Multicenter EMBRACE I Study
Int J Radiat Oncol Biol Phys, 113 (2), 379-389
DOI 10.1016/j.ijrobp.2022.02.005, PubMed 35157992

Niehusmann P, Stensvold E, Leske H, Pietsch T, Goschzik T, Gielen GH, Due-Tønnessen B, Frič R, Nilssen Y, Brandal P (2022)
Molecular pathological insights reveal a high number of unfavorable risk patients among children treated for medulloblastoma and CNS-PNET in Oslo 2005-2017
Pediatr Blood Cancer, 69 (9), e29736
DOI 10.1002/pbc.29736, PubMed 35570402

Nilsen A, Hillestad T, Skingen VE, Aarnes EK, Fjeldbo CS, Hompland T, Evensen TS, Stokke T, Kristensen GB, Grallert B, Lyng H (2022)
miR-200a/b/-429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer
Mol Oncol, 16 (6), 1402-1419
DOI 10.1002/1878-0261.13184, PubMed 35064630

Nilssen Y, Brustugun OT, Eriksen MT, Guren MG, Haug ES, Naume B, Schlichting E, Møller B (2022)
Compliance with recommended cancer patient pathway timeframes and choice of treatment differed by cancer type and place of residence among cancer patients in Norway in 2015-2016
BMC Cancer, 22 (1), 220
DOI 10.1186/s12885-022-09306-9, PubMed 35227226

Papoutsis I, Skjei Knudtsen I, Peter Skaug Sande E, Louni Rekstad B, Öllers M, van Elmpt W, Røthe Arnesen M, Malinen E (2022)
Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom
Phys Imaging Radiat Oncol, 21, 101-107
DOI 10.1016/j.phro.2022.02.013, PubMed 35243040

Preusser M, Silvani A, Le Rhun E, Soffietti R, Lombardi G, Sepulveda JM, Brandal P, Brazil L, Bonneville-Levard A, Lorgis V, Vauleon E, Bromberg J, Erridge S, Cameron A, Lefranc F, Clement PM, Dumont S, Sanson M, Bronnimann C, Balaná C, Thon N, Lewis J, Mair MJ, Sievers P, Furtner J et al. (2022)
Trabectedin for recurrent WHO grade 2 or 3 meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)
Neuro Oncol, 24 (5), 755-767
DOI 10.1093/neuonc/noab243, PubMed 34672349

Rao S, Anandappa G, Capdevila J, Dahan L, Evesque L, Kim S, Saunders MP, Gilbert DC, Jensen LH, Samalin E, Spindler KL, Tamberi S, Demols A, Guren MG, Arnold D, Fakih M, Kayyal T, Cornfeld M, Tian C, Catlett M, Smith M, Spano JP (2022)
A phase II study of retifanlimab (INCMGA00012) in patients with squamous carcinoma of the anal canal who have progressed following platinum-based chemotherapy (POD1UM-202)
ESMO Open, 7 (4), 100529 (in press)
DOI 10.1016/j.esmoop.2022.100529, PubMed 35816951

Rowsell A, Sodergren SC, Vassiliou V, Darlington AS, Guren MG, Alkhaffaf B, Moorbey C, Dennis K, Terada M (2022)
Systematic review of health-related quality of life (HRQoL) issues associated with gastric cancer: capturing cross-cultural differences
Gastric Cancer, 25 (4), 665-677
DOI 10.1007/s10120-022-01309-6, PubMed 35689705

Ryg U, Seierstad T, Nilsen LB, Hellebust TP, Djupvik LH, Gustafson H, Hydal J, Kishan AU, Hole KH, Lilleby W (2022)
A Prospective Study of High Dose-Rate Brachytherapy or Stereotactic Body Radiotherapy of Intra-Prostatic Recurrence: Toxicity and Long Term Clinical Outcome
Front Oncol, 12, 861127
DOI 10.3389/fonc.2022.861127, PubMed 35463376

Salberg UB, Skingen VE, Fjeldbo CS, Hompland T, Ragnum HB, Vlatkovic L, Hole KH, Seierstad T, Lyng H (2022)
A prognostic hypoxia gene signature with low heterogeneity within the dominant tumour lesion in prostate cancer patients
Br J Cancer, 127 (2), 321-328
DOI 10.1038/s41416-022-01782-x, PubMed 35332267

Segelov E, Guren MG, Sebag-Montefiore D, Rao S, Johnsson A, Franco P, Deutsch E, Arnold D, Spindler KG (2022)
"Global Multidisciplinary Team Meetings": Challenging Cases Virtual Forums from the International Multidisciplinary Anal Cancer Conference (IMACC)
Clin Colorectal Cancer (in press)
DOI 10.1016/j.clcc.2022.02.006, PubMed 35346604

Silwal-Pandit L, Stålberg SM, Henrik J. Johansson, Georgios Mermelekas, Lothe IMB, Skrede ML, Dalsgaard AM, Nebdal D, Helland, Lingjærde OC, Labori KJ, Skålhegg BS, Janne Lehtiö, Kure EH (2022)
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Cancer Res Commun, 2 (6), 434-446
DOI 10.1158/2767-9764.CRC-21-0100, PublikaID 411

Solberg S, Nilssen Y, Terje Brustugun O, Magnus Haram P, Helland Å, Møller B, Strand TE, Gyrid Freim Wahl S, Fjellbirkeland L (2022)
Concordance between clinical and pathology TNM-staging in lung cancer
Lung Cancer, 171, 65-69 (in press)
DOI 10.1016/j.lungcan.2022.07.014, PubMed 35926242

Switlyk MD, Lilleby W (2022)
The Classic Form of Progressive Multifocal Leukoencephalopathy in Advanced Prostate Cancer: a Case Report
SN Comprehensive Clinical Medicine, 4 (1), 43
DOI 10.1007/s42399-022-01125-0, PublikaID 393

Tanem KE, Stensvold E, Wilberg P, Skaare AB, Singh PB, Brandal P, Herlofson BB (2022)
Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET
Support Care Cancer, 30 (7), 6155-6162
DOI 10.1007/s00520-022-07048-9, PubMed 35426047

Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES, CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R, InPreD-Norway and National Molecular Tumor Board Consortium, IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å (2022)
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529

Theophanous S, Lønne PI, Choudhury A, Berbee M, Dekker A, Dennis K, Dewdney A, Gambacorta MA, Gilbert A, Guren MG, Holloway L, Jadon R, Kochhar R, Mohamed AA, Muirhead R, Parés O, Raszewski L, Roy R, Scarsbrook A, Sebag-Montefiore D, Spezi E, Spindler KG, van Triest B, Vassiliou V, Malinen E et al. (2022)
Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study
Diagn Progn Res, 6 (1), 14
DOI 10.1186/s41512-022-00128-8, PubMed 35922837

Umu SU, Langseth H, Zuber V, Helland Å, Lyle R, Rounge TB (2022)
Serum RNAs can predict lung cancer up to 10 years prior to diagnosis
Elife, 11
DOI 10.7554/eLife.71035, PubMed 35147498

Westerveld H, Kirchheiner K, Nout RA, Tanderup K, Lindegaard JC, Spampinato S, Sturdza A, Nesvacil N, Bruheim K, Hellebust TP, Pieters BR, Kirisits C, Jürgenliemk-Schulz IM, Pötter R, de Leeuw AAC (2022)
Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study
Radiother Oncol, 168, 8-15
DOI 10.1016/j.radonc.2021.12.034, PubMed 35063582

Publications 2021

Aljabri B, Lilleby W, Switlyk MD, Tafjord G (2021)
Restart of androgen deprivation therapy after goserelin induced pituitary apoplexy in a patient with disseminated prostate cancer a case report and five-years follow-up
Urol Case Rep, 37, 101648
DOI 10.1016/j.eucr.2021.101648, PubMed 33868933

Álvarez-Torres MDM, Fuster-García E, Reynés G, Juan-Albarracín J, Chelebian E, Oleaga L, Pineda J, Auger C, Rovira A, Emblem KE, Filice S, Mollà-Olmos E, García-Gómez JM (2021)
Differential effect of vascularity between long- and short-term survivors with IDH1/2 wild-type glioblastoma
NMR Biomed, 34 (4), e4462
DOI 10.1002/nbm.4462, PubMed 33470039

Areklett EW, Fagereng E, Bruheim K, Andersson S, Lindemann K (2021)
Self-reported cognitive impairment in cervical cancer survivors: A cross-sectional study
Psychooncology, 31 (2), 298-305
DOI 10.1002/pon.5818, PubMed 34516040

Asperud J, Arous D, Edin NFJ, Malinen E (2021)
Spatially fractionated radiotherapy: tumor response modelling including immunomodulation
Phys Med Biol, 66 (17)
DOI 10.1088/1361-6560/ac176b, PubMed 34298527

Bahadoer RR, Bastiaannet E, Claassen YHM, van der Mark M, van Eycken E, Verbeeck J, Guren MG, Kørner H, Martling A, Johansson R, van de Velde CJH, Dekker JWT (2021)
One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison
Eur J Surg Oncol, 47 (7), 1651-1660
DOI 10.1016/j.ejso.2021.01.011, PubMed 33518367

Bannier E, Barker G, Borghesani V, Broeckx N, Clement P, Emblem KE, Ghosh S, Glerean E, Gorgolewski KJ, Havu M, Halchenko YO, Herholz P, Hespel A, Heunis S, Hu Y, Hu CP, Huijser D, de la Iglesia Vayá M, Jancalek R, Katsaros VK, Kieseler ML, Maumet C, Moreau CA, Mutsaerts HJ, Oostenveld R et al. (2021)
The Open Brain Consent: Informing research participants and obtaining consent to share brain imaging data
Hum Brain Mapp, 42 (7), 1945-1951
DOI 10.1002/hbm.25351, PubMed 33522661

Berg J, Ramberg C, Haugstvedt JOS, Bengtson MB, Gabrielsen AM, Brustugun OT, Halvorsen AR, Helland Å (2021)
Lung Function After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer, Changes and Predictive Markers
Front Oncol, 11, 674731
DOI 10.3389/fonc.2021.674731, PubMed 34109123

Bjaanæs MM, Nilsen G, Halvorsen AR, Russnes HG, Solberg S, Jørgensen L, Brustugun OT, Lingjærde OC, Helland Å (2021)
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors
BMC Cancer, 21 (1), 1089
DOI 10.1186/s12885-021-08811-7, PubMed 34625038

Bruun J, Eide PW, Bergsland CH, Bruck O, Svindland A, Arjama M, Välimäki K, Bjørnslett M, Guren MG, Kallioniemi O, Nesbakken A, Lothe RA, Pellinen T (2021)
E-cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models
Mol Oncol, 16 (12), 2312-2329
DOI 10.1002/1878-0261.13159, PubMed 34890102

Choudhury A, Theophanous S, Lønne PI, Samuel R, Guren MG, Berbee M, Brown P, Lilley J, van Soest J, Dekker A, Gilbert A, Malinen E, Wee L, Appelt AL (2021)
Predicting outcomes in anal cancer patients using multi-centre data and distributed learning - A proof-of-concept study
Radiother Oncol, 159, 183-189
DOI 10.1016/j.radonc.2021.03.013, PubMed 33753156

Due-Tønnessen P, Pinho MC, Emblem KE, Hald JK, Kanoto M, Abildgaard A, Sederevicius D, Groote IR, Rapalino O, Bjørnerud A (2021)
Author Correction: The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma
Sci Rep, 11 (1), 20287
DOI 10.1038/s41598-021-99776-x, PubMed 34620996

Eide IJZ, Grut H, Helland Å, Ekman S, Sørensen JB, Hansen KH, Grønberg BH, Cicenas S, Koivunen JP, Mellemgaard A, Brustugun OT (2021)
Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study
Acta Oncol, 60 (12), 1565-1571
DOI 10.1080/0284186X.2021.1973092, PubMed 34486915

Farooqi SJ, Bjaanæs MM, Helland Å, Haakensen VD (2021)
Immunotherapy for malignant pleural mesothelioma
Tidsskr Nor Laegeforen, 141
DOI 10.4045/tidsskr.21.0503, PubMed 34505475

Farooqi SJ, Helland A, Haakensen VD, Bjaanaes MM (2021)
Immunotherapy in malignant pleural mesothelioma
Tidsskr. Nor. Laegeforen., 141 (12), 1167-1169

Frafjord A, Buer L, Hammarström C, Aamodt H, Woldbæk PR, Brustugun OT, Helland Å, Øynebråten I, Corthay A (2021)
The Immune Landscape of Human Primary Lung Tumors Is Th2 Skewed
Front Immunol, 12, 764596
DOI 10.3389/fimmu.2021.764596, PubMed 34868011

Gorgen A, Guttormsen M, Larsen AC, Siem S, Adli E, Edin NFJ, Gjersdal H, Henriksen G, Malinen E, Modamio V, Schoultz B, Sobas PA, Theodossiou TA, Wikne JC (2021)
The Oslo Cyclotron Laboratory
Eur. Phys. J. Plus, 136 (2), 181
DOI 10.1140/epjp/s13360-021-01150-3

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2021)
Publisher Correction: Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 12 (1), 7073
DOI 10.1038/s41467-021-27175-x, PubMed 34848706

Groendahl AR, Moe YM, Kaushal CK, Huynh BN, Rusten E, Tomic O, Hernes E, Hanekamp B, Undseth C, Guren MG, Malinen E, Futsaether CM (2021)
Deep learning-based automatic delineation of anal cancer gross tumour volume: a multimodality comparison of CT, PET and MRI
Acta Oncol, 61 (1), 89-96
DOI 10.1080/0284186X.2021.1994645, PubMed 34783610

Groendahl AR, Skjei Knudtsen I, Huynh BN, Mulstad M, Moe YM, Knuth F, Tomic O, Indahl UG, Torheim T, Dale E, Malinen E, Futsaether CM (2021)
A comparison of methods for fully automatic segmentation of tumors and involved nodes in PET/CT of head and neck cancers
Phys Med Biol, 66 (6), 065012
DOI 10.1088/1361-6560/abe553, PubMed 33666176

Grøvik E, Yi D, Iv M, Tong E, Nilsen LB, Latysheva A, Saxhaug C, Jacobsen KD, Helland Å, Emblem KE, Rubin DL, Zaharchuk G (2021)
Handling missing MRI sequences in deep learning segmentation of brain metastases: a multicenter study
NPJ Digit Med, 4 (1), 33
DOI 10.1038/s41746-021-00398-4, PubMed 33619361

Guldvik IJ, Ekseth L, Kishan AU, Stensvold A, Inderberg EM, Lilleby W (2021)
Circulating Tumor Cell Persistence Associates with Long-Term Clinical Outcome to a Therapeutic Cancer Vaccine in Prostate Cancer
J Pers Med, 11 (7)
DOI 10.3390/jpm11070605, PubMed 34206815

Guren MG, Sebag-Montefiore D, Franco P, Johnsson A, Segelov E, Deutsch E, Rao S, Spindler KG, Arnold D (2021)
Treatment of Squamous Cell Carcinoma of the Anus, Unresolved Areas and Future Perspectives for Research: Perspectives of Research Needs in Anal Cancer
Clin Colorectal Cancer, 20 (4), 279-287
DOI 10.1016/j.clcc.2021.09.006, PubMed 34645589

Hamfjord J, Myklebust TÅ, Larsen IK, Kure EH, Glimelius B, Guren TK, Tveit KM, Guren MG (2021)
Survival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study
Cancer Epidemiol Biomarkers Prev, 31 (2), 342-351
DOI 10.1158/1055-9965.EPI-21-0555, PubMed 34853022

Hauge S, Eek Mariampillai A, Rødland GE, Bay LTE, Landsverk HB, Syljuåsen RG (2021)
Expanding roles of cell cycle checkpoint inhibitors in radiation oncology
Int J Radiat Biol
DOI 10.1080/09553002.2021.1913529, PubMed 33877959

Hernes E, Revheim ME, Hole KH, Tulipan AJ, Strømme H, Lilleby W, Seierstad T (2021)
Prostate-Specific Membrane Antigen PET for Assessment of Primary and Recurrent Prostate Cancer with Histopathology as Reference Standard: A Systematic Review and Meta-Analysis
PET Clin, 16 (2), 147-165
DOI 10.1016/j.cpet.2020.12.001, PubMed 33648661

Hompland T, Fjeldbo CS, Lyng H (2021)
Tumor Hypoxia as a Barrier in Cancer Therapy: Why Levels Matter
Cancers (Basel), 13 (3)
DOI 10.3390/cancers13030499, PubMed 33525508

Husum YS, Skogen K, Brandal P, Rønning PA, Wigers AR, Evang JA, Jørstad ØK (2021)
Bilateral calcification of the optic nerve sheath: A diagnostic dilemma
Am J Ophthalmol Case Rep, 22, 101106
DOI 10.1016/j.ajoc.2021.101106, PubMed 33997471

Haakensen VD, Nowak AK, Ellingsen EB, Farooqi SJ, Bjaanæs MM, Horndalsveen H, Mcculloch T, Grundberg O, Cedres SM, Helland Å (2021)
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma
J Transl Med, 19 (1), 232
DOI 10.1186/s12967-021-02905-3, PubMed 34059094

Johannesen TB, Smeland S, Aaserud S, Buanes EA, Skog A, Ursin G, Helland Å (2021)
COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway
Front Oncol, 11, 652535
DOI 10.3389/fonc.2021.652535, PubMed 33842366

Johnson ML, Zvirbule Z, Laktionov K, Helland A, Cho BC, Gutierrez V, Colinet B, Lena H, Wolf M, Gottfried M, Okamoto I, van der Leest C, Rich P, Hung JY, Appenzeller C, Sun Z, Maag D, Luo Y, Nickner C, Vajikova A, Komarnitsky P, Bar J (2021)
Rovalpituzumab Tesirine as a Maintenance Therapy After First-Line Platinum-Based Chemotherapy in Patients With Extensive-Stage-SCLC: Results From the Phase 3 MERU Study
J Thorac Oncol, 16 (9), 1570-1581
DOI 10.1016/j.jtho.2021.03.012, PubMed 33823285

Karlsson AT, Hjermstad MJ, Omdahl T, Aass N, Skovlund E, Hellebust TP, Johansen S, Kaasa S, Yri OE (2021)
Overall survival after initial radiotherapy for brain metastases; a population based study of 2140 patients with non-small cell lung cancer
Acta Oncol, 60 (8), 1054-1060
DOI 10.1080/0284186X.2021.1924399, PubMed 34032536

Kim M, Park JE, Emblem K, Bjørnerud A, Kim HS (2021)
Vessel Type Determined by Vessel Architectural Imaging Improves Differentiation between Early Tumor Progression and Pseudoprogression in Glioblastoma
AJNR Am J Neuroradiol, 42 (4), 663-670
DOI 10.3174/ajnr.A6984, PubMed 33541891

Kirchheiner K, Smet S, Jürgenliemk-Schulz IM, Haie-Meder C, Chargari C, Lindegaard JC, Fokdal LU, Spampinato S, Schmid MP, Sturdza A, Mahantshetty U, Segedin B, Bruheim K, Rai B, Cooper R, Van der Steen-Banasik E, Wiebe E, Sundset M, van Limbergen E, Villafranca E, Westerveld H, Tan LT, Pötter R, Tanderup K, Nout RA et al. (2021)
Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study
Int J Radiat Oncol Biol Phys, 112 (2), 400-413
DOI 10.1016/j.ijrobp.2021.08.036, PubMed 34478833

Kryeziu K, Moosavi SH, Bergsland CH, Guren MG, Eide PW, Totland MZ, Lassen K, Abildgaard A, Nesbakken A, Sveen A, Lothe RA (2021)
Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases
J Transl Med, 19 (1), 384
DOI 10.1186/s12967-021-03062-3, PubMed 34496878

Landsverk HB, Sandquist LE, Bay LTE, Syljuåsen RG (2021)
New link between the RNA polymerase II-CTD and replication stress
Mol Cell Oncol, 8 (3), 1910008
DOI 10.1080/23723556.2021.1910008, PubMed 34027044

Lehtiö J, Arslan T, Siavelis I, Pan Y, Socciarelli F, Berkovska O, Umer HM, Mermelekas G, Pirmoradian M, Jönsson M, Brunnström H, Brustugun OT, Purohit KP, Cunningham R, Foroughi Asl H, Isaksson S, Arbajian E, Aine M, Karlsson A, Kotevska M, Gram Hansen C, Drageset Haakensen V, Helland Å, Tamborero D, Johansson HJ et al. (2021)
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms
Nat Cancer, 2 (11), 1224-1242
DOI 10.1038/s43018-021-00259-9, PubMed 34870237

Lindemann K, Smogeli E, Småstuen MC, Bruheim K, Trovik J, Nordberg T, Kristensen GB, Werner HMJ, Nakken E (2021)
Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer
Cancers (Basel), 13 (6)
DOI 10.3390/cancers13061367, PubMed 33803531

Lundar T, Due-Tønnessen BJ, Frič R, Brandal P, Due-Tønnessen P (2021)
Choroid Plexus Tumors in Children: Long-Term Follow-Up of Consecutive Single-Institutional Series of 59 Patients Treated over a Period of 8 Decades (1939-2020)
World Neurosurg, 158, e810-e819
DOI 10.1016/j.wneu.2021.11.070, PubMed 34823041

Lundar T, Due-Tønnessen BJ, Frič R, Sundseth J, Brandal P, Due-Tønnessen P (2021)
Outcome After Treatment of Spinal Ependymoma in Children and Adolescents: Long-Term Follow-up of a Single Consecutive Institutional Series of 33 Patients Treated Over Eight Decades
World Neurosurg, 150, e228-e235
DOI 10.1016/j.wneu.2021.02.131, PubMed 33684583

Lundar T, Due-Tønnessen BJ, Frič R, Sundseth J, Brandal P, Due-Tønnessen P (2021)
Outcome after treatment of pediatric supratentorial ependymoma: long-term follow-up of a single consecutive institutional series of 26 patients
Br J Neurosurg
DOI 10.1080/02688697.2021.1914821, PubMed 34096810

Moe YM, Groendahl AR, Tomic O, Dale E, Malinen E, Futsaether CM (2021)
Deep learning-based auto-delineation of gross tumour volumes and involved nodes in PET/CT images of head and neck cancer patients
Eur J Nucl Med Mol Imaging, 48 (9), 2782-2792
DOI 10.1007/s00259-020-05125-x, PubMed 33559711

Moosavi SH, Eide PW, Eilertsen IA, Brunsell TH, Berg KCG, Røsok BI, Brudvik KW, Bjørnbeth BA, Guren MG, Nesbakken A, Lothe RA, Sveen A (2021)
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
Genome Med, 13 (1), 143
DOI 10.1186/s13073-021-00956-1, PubMed 34470666

Nakken S, Lilleby W, Switlyk MD, Knudsen KE, Lilleby O, Zhao S, Kaveh F, Ekstrøm PO, Urbanucci A, Hovig E (2021)
The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology
J Pers Med, 11 (5)
DOI 10.3390/jpm11050330, PubMed 33922147

Nilssen Y, Eriksen MT, Guren MG, Møller B (2021)
Factors associated with emergency-onset diagnosis, time to treatment and type of treatment in colorectal cancer patients in Norway
BMC Cancer, 21 (1), 757
DOI 10.1186/s12885-021-08415-1, PubMed 34187404

Osterman E, Ekström J, Sjöblom T, Kørner H, Myklebust TÅ, Guren MG, Glimelius B (2021)
Accurate population-based model for individual prediction of colon cancer recurrence
Acta Oncol, 60 (10), 1241-1249
DOI 10.1080/0284186X.2021.1953138, PubMed 34279175

Peters M, de Leeuw AAC, Nomden CN, Tanderup K, Kirchheiner K, Lindegaard JC, Kirisits C, Haie-Meder C, Sturdza A, Fokdal L, Mahantshetty U, Hoskin P, Segedin B, Bruheim K, Rai B, Huang F, Cooper R, van der Steen-Banasik E, van Limbergen E, Pieters BR, Tan LT, van Rossum PSN, Nesvacil N, Nout R, Schmid MP et al. (2021)
Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis
Radiother Oncol, 163, 150-158
DOI 10.1016/j.radonc.2021.08.020, PubMed 34480958

Petr J, Hogeboom L, Nikulin P, Wiegers E, Schroyen G, Kallehauge J, Chmelík M, Clement P, Nechifor RE, Fodor LA, De Witt Hamer PC, Barkhof F, Pernet C, Lequin M, Deprez S, Jančálek R, Mutsaerts HJMM, Pizzini FB, Emblem KE, Keil VC (2021)
A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue
MAGMA, 35 (1), 163-186
DOI 10.1007/s10334-021-00985-2, PubMed 34919195

Pilleron S, Charvat H, Araghi M, Arnold M, Fidler-Benaoudia MM, Bardot A, Guren MG, Tervonen H, Little A, O'Connell DL, Gavin A, De P, Thomsen LA, Moller B, Jackson C, Bucher O, Walsh PM, Vernon S, Bray F, Soerjomataram I (2021)
Age disparities in stage-specific colon cancer survival across seven countries: An International Cancer Benchmarking Partnership SURVMARK-2 population-based study. (vol 148, 1575, 2021)
Int. J. Cancer, 149 (6), E9
DOI 10.1002/ijc.33717

Popat S, Brustugun OT, Cadranel J, Felip E, Garassino MC, Griesinger F, Helland Å, Hochmair M, Pérol M, Bent-Ennakhil N, Kruhl C, Novello S (2021)
Real-world treatment outcomes with brigatinib in patients with pretreated ALK+ metastatic non-small cell lung cancer
Lung Cancer, 157, 9-16
DOI 10.1016/j.lungcan.2021.05.017, PubMed 34051652

Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C et al. (2021)
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study
Lancet Oncol, 22 (4), 538-547
DOI 10.1016/S1470-2045(20)30753-1, PubMed 33794207

Rao S, Guren MG, Khan K, Brown G, Renehan AG, Steigen SE, Deutsch E, Martinelli E, Arnold D, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org (2021)
Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up^☆
Ann Oncol, 32 (9), 1087-1100
DOI 10.1016/j.annonc.2021.06.015, PubMed 34175386

REACCT Collaborative, Zaborowski AM, Abdile A, Adamina M, Aigner F, d'Allens L, Allmer C, Álvarez A, Anula R, Andric M, Atallah S, Bach S, Bala M, Barussaud M, Bausys A, Bebington B, Beggs A, Bellolio F, Bennett MR, Berdinskikh A, Bevan V, Biondo S, Bislenghi G, Bludau M, Boutall A et al. (2021)
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review
JAMA Surg, 156 (9), 865-874
DOI 10.1001/jamasurg.2021.2380, PubMed 34190968

Rødland GE, Hauge S, Hasvold G, Bay LTE, Raabe TTH, Joel M, Syljuåsen RG (2021)
Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells
Cancers (Basel), 13 (15)
DOI 10.3390/cancers13153790, PubMed 34359691

Rønde HS, Kallehauge JF, Kronborg CJS, Nyvang L, Rekstad BL, Hanekamp BA, Appelt AL, Guren MG, Spindler KLS (2021)
Intensity modulated proton therapy planning study for organ at risk sparing in rectal cancer re-irradiation
Acta Oncol, 60 (11), 1436-1439
DOI 10.1080/0284186X.2021.1953139, PubMed 34264785

Seierstad T, Hole KH, Tulipan AJ, Strømme H, Lilleby W, Revheim ME, Hernes E (2021)
¹⁸F-Fluciclovine PET for Assessment of Prostate Cancer with Histopathology as Reference Standard: A Systematic Review
PET Clin, 16 (2), 167-176
DOI 10.1016/j.cpet.2020.12.012, PubMed 33648662

Seland M, Skrede K, Lindemann K, Skaali T, Blomhoff R, Bruheim K, Wisløff T, Thorsen L (2021)
Distress, problems and unmet rehabilitation needs after treatment for gynecological cancer
Acta Obstet Gynecol Scand, 101 (3), 313-322
DOI 10.1111/aogs.14310, PubMed 34964982

Skaga E, Skretteberg MA, Johannesen TB, Brandal P, Vik-Mo EO, Helseth E, Langmoen IA (2021)
Real-world validity of randomized controlled phase III trials in newly diagnosed glioblastoma: to whom do the results of the trials apply?
Neurooncol Adv, 3 (1), vdab008
DOI 10.1093/noajnl/vdab008, PubMed 33665615

Slørdahl KS, Klotz D, Olsen JÅ, Skovlund E, Undseth C, Abildgaard HL, Brændengen M, Nesbakken A, Larsen SG, Hanekamp BA, Holmboe L, Tvedt R, Sveen A, Lothe RA, Malinen E, Kaasa S, Guren MG (2021)
Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer
Acta Oncol, 60 (7), 921-930
DOI 10.1080/0284186X.2021.1918763, PubMed 33966592

Smet S, Spampinato S, Pötter R, Jürgenliemk-Schulz IM, Nout RA, Chargari C, Mahantshetty U, Sturdza A, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, Van der Steen-Banasik E, Sundset M, Van Limbergen E, Tan LT, Lutgens LCHW, Villafranca E, Pieters BR, Tanderup K, Kirchheiner K (2021)
Risk Factors for Late Persistent Fatigue After Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: An Analysis From the EMBRACE-I Study
Int J Radiat Oncol Biol Phys, 112 (5), 1177-1189
DOI 10.1016/j.ijrobp.2021.11.022, PubMed 34838868

Spampinato S, Fokdal LU, Pötter R, Haie-Meder C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, van der Steen-Banasik E, Van Limbergen E, Sundset M, Westerveld H, Nout RA, Jensen NBK, Kirisits C, Kirchheiner K, Tanderup K, EMBRACE Collaborative Group (2021)
Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis
Radiother Oncol, 158, 312-320
DOI 10.1016/j.radonc.2021.01.019, PubMed 33545254

Spampinato S, Fokdal LU, Pötter R, Haie-Meder C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, van der Steen-Banasik E, Van Limbergen E, Sundset M, Westerveld H, Nout RA, Jensen NBK, Kirisits C, Kirchheiner K, Tanderup K, EMBRACE Collaborative Group (2021)
Response to Yuce Sari et al
Radiother Oncol, 158, 323-324
DOI 10.1016/j.radonc.2021.02.022, PubMed 33647355

Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N et al. (2021)
Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future
Int J Radiat Oncol Biol Phys, 112 (3), 681-693
DOI 10.1016/j.ijrobp.2021.09.055, PubMed 34678431

Svensson SF, De Arcos J, Darwish OI, Fraser-Green J, Storås TH, Holm S, Vik-Mo EO, Sinkus R, Emblem KE (2021)
Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods
J Magn Reson Imaging, 53 (5), 1510-1521
DOI 10.1002/jmri.27475, PubMed 33403750

Switlyk MD, Niehusmann P, Sprauten M, Magelssen H, Aarhus M, Rasmussen FØ, Knutstad K, Brandal P (2021)
Neurosarcoidosis resembling multiple meningiomas: A misleading presentation of the disease and diagnostic challenge
Acta Radiol Open, 10 (7), 20584601211036550
DOI 10.1177/20584601211036550, PubMed 34377543

Torstveit AH, Løyland B, Grov EK, Guren M, Paul SM, Ritchie C, Vistad I, Miaskowski C, Utne I (2021)
Distinctions Between Self-Report and Performance-Based Measures of Physical Function in Older Patients Prior to Chemotherapy
Cancer Nurs, 44 (6), E735-E744
DOI 10.1097/NCC.0000000000000964, PubMed 34183518

Torstveit AH, Miaskowski C, Løyland B, Grov EK, Guren MG, Ritchie CS, Paul SM, Kleven AG, Utne I (2021)
Common and distinct characteristics associated with self-reported functional status in older patients with cancer receiving chemotherapy
Eur J Oncol Nurs, 54, 102033
DOI 10.1016/j.ejon.2021.102033, PubMed 34537538

Toussaint L, Brandal P, Embring A, Engellau J, Evensen ME, Griskeviskius R, Hansen J, Hietala H, Wickart Johansson G, Jørgensen M, Kramer PH, Kristensen I, Lehtio K, Magelssen H, Maraldo MV, Marienhagen K, Martinsson U, Nilsson K, Peters S, Plaude S, Seiersen K, Sendiuliene D, Smulders B, Edvardsen T, Søbstad JM et al. (2021)
Inter-observer variation in target delineation and dose trade-off for radiotherapy of paediatric ependymoma
Acta Oncol, 61 (2), 235-238
DOI 10.1080/0284186X.2021.2022202, PubMed 34970940

Tryggestad AMA, Axcrona K, Axcrona U, Bigalke I, Brennhovd B, Inderberg EM, Hønnåshagen TK, Skoge LJ, Solum G, Saebøe-Larssen S, Josefsen D, Olaussen RW, Aamdal S, Skotheim RI, Myklebust TÅ, Schendel DJ, Lilleby W, Dueland S, Kvalheim G (2021)
Long-term first-in-man Phase I/II study of an adjuvant dendritic cell vaccine in patients with high-risk prostate cancer after radical prostatectomy
Prostate, 82 (2), 245-253
DOI 10.1002/pros.24267, PubMed 34762317

Tulipan AJ, Salberg UB, Hole KH, Vlatkovic L, Aarnes EK, Revheim ME, Lyng H, Seierstad T (2021)
Amino acid transporter expression and 18F-FACBC uptake at PET in primary prostate cancer
Am J Nucl Med Mol Imaging, 11 (4), 250-259
PubMed 34513278

Wright P, Arnesen MR, Lønne PI, Suilamo S, Silvoniemi A, Dale E, Minn H, Malinen E (2021)
Repeatability of hypoxia dose painting by numbers based on EF5-PET in head and neck cancer
Acta Oncol, 60 (11), 1386-1391
DOI 10.1080/0284186X.2021.1944663, PubMed 34184605

Yi D, Grøvik E, Tong E, Iv M, Emblem KE, Nilsen LB, Saxhaug C, Latysheva A, Jacobsen KD, Helland Å, Zaharchuk G, Rubin D (2021)
MRI pulse sequence integration for deep-learning-based brain metastases segmentation
Med Phys, 48 (10), 6020-6035
DOI 10.1002/mp.15136, PubMed 34405896

Öjlert ÅK, Nebdal D, Snapkov I, Olsen V, Kidman J, Greiff V, Chee J, Helland Å (2021)
Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor
Mol Oncol, 15 (11), 2958-2968
DOI 10.1002/1878-0261.13082, PubMed 34402187

Publications 2020

Abravan A, Eide HA, Helland Å, Malinen E (2020)
Radiotherapy-related lymphopenia in patients with advanced non-small cell lung cancer receiving palliative radiotherapy
Clin Transl Radiat Oncol, 22, 15-21
DOI 10.1016/j.ctro.2020.02.005, PubMed 32181373

Al-Haidari G, Skovlund E, Undseth C, Rekstad BL, Larsen SG, Åsli LM, Dueland S, Malinen E, Guren MG (2020)
Re-irradiation for recurrent rectal cancer - a single-center experience
Acta Oncol, 59 (5), 534-540
DOI 10.1080/0284186X.2020.1725111, PubMed 32056476

Araghi M, Arnold M, Rutherford MJ, Guren MG, Cabasag CJ, Bardot A, Ferlay J, Tervonen H, Shack L, Woods RR, Saint-Jacques N, De P, McClure C, Engholm G, Gavin AT, Morgan E, Walsh PM, Jackson C, Porter G, Møller B, Bucher O, Eden M, O'Connell DL, Bray F, Soerjomataram I (2020)
Colon and rectal cancer survival in seven high-income countries 2010-2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project)
Gut, 70 (1), 114-126
DOI 10.1136/gutjnl-2020-320625, PubMed 32482683

Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP, RAPIDO collaborative investigators (2020)
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial
Lancet Oncol, 22 (1), 29-42
DOI 10.1016/S1470-2045(20)30555-6, PubMed 33301740

Bangalore Yogananda CG, Shah BR, Vejdani-Jahromi M, Nalawade SS, Murugesan GK, Yu FF, Pinho MC, Wagner BC, Emblem KE, Bjørnerud A, Fei B, Madhuranthakam AJ, Maldjian JA (2020)
A Fully Automated Deep Learning Network for Brain Tumor Segmentation
Tomography, 6 (2), 186-193
DOI 10.18383/j.tom.2019.00026, PubMed 32548295

Bell L, Holloway L, Bruheim K, Petrič P, Kirisits C, Tanderup K, Pötter R, Vinod S, Lim K, Pogson E, Metcalfe P, Hellebust TP (2020)
Dose planning variations related to delineation variations in MRI-guided brachytherapy for locally advanced cervical cancer
Brachytherapy, 19 (2), 146-153
DOI 10.1016/j.brachy.2020.01.002, PubMed 32067884

Bergsland CH, Bruun J, Guren MG, Svindland A, Bjørnslett M, Smeby J, Hektoen M, Kolberg M, Domingo E, Pellinen T, Tomlinson I, Kerr D, Church DN, Nesbakken A, Sveen A, Lothe RA (2020)
Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer
ESMO Open, 5 (6), e001040
DOI 10.1136/esmoopen-2020-001040, PubMed 33219056

Brandal P, Bergfeldt K, Aggerholm-Pedersen N, Bäckström G, Kerna I, Gubanski M, Björnlinger K, Evensen ME, Kuddu M, Pettersson E, Brydøy M, Hellebust TP, Dale E, Valdman A, Weber L, Høyer M (2020)
A Nordic-Baltic perspective on indications for proton therapy with strategies for identification of proper patients
Acta Oncol, 59 (10), 1157-1163
DOI 10.1080/0284186X.2020.1817977, PubMed 32902341

Breugom AJ, Bastiaannet E, Guren MG, Kørner H, Boelens PG, Dekker FW, Kapiteijn E, Gelderblom H, Larsen IK, Liefers GJ, van de Velde CJH (2020)
Treatment strategies and overall survival for incurable metastatic colorectal cancer - A EURECCA international comparison including 21,196 patients from the Netherlands and Norway
Eur J Surg Oncol, 46 (6), 1167-1173
DOI 10.1016/j.ejso.2020.02.005, PubMed 32151531

Brustugun OT, Sorhaug S, Gronberg BH, Aanerud M, Al-Zubayidy MMZ, Fjellbirkeland L, Helland A, Berg J, Andreassen B, Paulsen EE, Haram PM, Ashraf H, Wahl SGF (2020)
Lung cancer: Improved prognosis presents capacity challenges
Tidsskr. Nor. Laegeforen., 140 (5), 432-434

Brustugun OT, Sørhaug S, Grønberg BH, Aanerud M, Al-Zubayidy MMZ, Fjellbirkeland L, Helland Å, Berg J, Andreassen B, Paulsen EE, Haram PM, Ashraf H, Wahl SGF (2020)
Lung cancer: Improved prognosis results in capacity challenges
Tidsskr Nor Laegeforen, 140 (5)
DOI 10.4045/tidsskr.20.0014, PubMed 32238965

Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA (2020)
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity
Clin Cancer Res, 26 (15), 4107-4119
DOI 10.1158/1078-0432.CCR-19-3637, PubMed 32299813

Chen C, Wei Y, Wei L, Chen J, Chen X, Dong X, He J, Lin L, Zhu Y, Huang H, You D, Lai L, Shen S, Duan W, Su L, Shafer A, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Wang R, Staaf J, Helland Å, Esteller M, Zhang R et al. (2020)
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
Aging (Albany NY), 12 (11), 10642-10662
DOI 10.18632/aging.103284, PubMed 32511103

Clarke M, Mackay A, Ismer B, Pickles JC, Tatevossian RG, Newman S, Bale TA, Stoler I, Izquierdo E, Temelso S, Carvalho DM, Molinari V, Burford A, Howell L, Virasami A, Fairchild AR, Avery A, Chalker J, Kristiansen M, Haupfear K, Dalton JD, Orisme W, Wen J, Hubank M, Kurian KM et al. (2020)
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Cancer Discov, 10 (7), 942-963
DOI 10.1158/2159-8290.CD-19-1030, PubMed 32238360

Clement P, Booth T, Borovečki F, Emblem KE, Figueiredo P, Hirschler L, Jančálek R, Keil VC, Maumet C, Özsunar Y, Pernet C, Petr J, Pinto J, Smits M, Warnert EAH (2020)
GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma
J Med Biol Eng, 41 (2), 115-125
DOI 10.1007/s40846-020-00582-z, PubMed 33293909

Dahl O, Myklebust MP, Dale JE, Leon O, Serup-Hansen E, Jakobsen A, Pfeiffer P, Løes IM, Pfeffer F, Spindler KG, Guren MG, Glimelius B, Johnsson A (2020)
Evaluation of the stage classification of anal cancer by the TNM 8th version versus the TNM 7th version
Acta Oncol, 59 (9), 1016-1023
DOI 10.1080/0284186X.2020.1778180, PubMed 32574087

Dahle TJ, Rusten E, Stokkevåg CH, Silvoniemi A, Mairani A, Fjæra LF, Rørvik E, Henjum H, Wright P, Boer CG, Forsback S, Minn H, Malinen E, Ytre-Hauge KS (2020)
The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
Phys Med, 76, 166-172
DOI 10.1016/j.ejmp.2020.07.003, PubMed 32683269

Deek M, Lilleby W, Vaage V, Hole KH, DeWeese T, Stensvold A, Tran P, Seierstad T (2020)
Impact of radiation dose on recurrence in high-risk prostate cancer patients
Prostate, 80 (15), 1322-1327
DOI 10.1002/pros.24059, PubMed 33258482

Digernes I, Nilsen LB, Grøvik E, Bjørnerud A, Løvland G, Vik-Mo E, Meling TR, Saxhaug C, Helland Å, Jacobsen KD, Geier O, Emblem KE (2020)
Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI
Phys Med Biol, 65 (22), 225020
DOI 10.1088/1361-6560/abb71a, PubMed 33200748

Eide IJZ, Helland Å, Ekman S, Mellemgaard A, Hansen KH, Cicenas S, Koivunen J, Grønberg BH, Brustugun OT (2020)
Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study)
Lung Cancer, 143, 27-35
DOI 10.1016/j.lungcan.2020.03.009, PubMed 32200138

Fjeldbo CS, Hompland T, Hillestad T, Aarnes EK, Günther CC, Kristensen GB, Malinen E, Lyng H (2020)
Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity
EBioMedicine, 57, 102841
DOI 10.1016/j.ebiom.2020.102841, PubMed 32580139

Fosså SD, Aas K, Müller C, Jerm MB, Tandstad T, Lilleby W, Kvåle R, Gulbrandsen J, Haug E, Myklebust TA (2020)
Definitive radiotherapy for prostate cancer in Norway 2006-2015: Temporal trends, performance and survival
Radiother Oncol, 155, 33-41
DOI 10.1016/j.radonc.2020.10.022, PubMed 33096165

Frafjord A, Skarshaug R, Hammarström C, Stankovic B, Dorg LT, Aamodt H, Woldbaek PR, Helland Å, Brustugun OT, Øynebråten I, Corthay A (2020)
Antibody combinations for optimized staining of macrophages in human lung tumours
Scand J Immunol, 92 (1), e12889
DOI 10.1111/sji.12889, PubMed 32299134

Frič R, Due-Tønnessen BJ, Lundar T, Egge A, Kronen Krossnes B, Due-Tønnessen P, Stensvold E, Brandal P (2020)
Long-term outcome of posterior fossa medulloblastoma in patients surviving more than 20 years following primary treatment in childhood
Sci Rep, 10 (1), 9371
DOI 10.1038/s41598-020-66328-8, PubMed 32523021

Frydenberg H, Harsem NK, Ofigsbø Å, Skoglund H, Brændengen M, Kaasa S, Guren MG (2020)
Chemotherapy During Pregnancy for Advanced Colon Cancer: A Case Report
Clin Colorectal Cancer, 19 (2), 141-144
DOI 10.1016/j.clcc.2020.02.013, PubMed 32222353

Fuster-Garcia E, Lorente Estellés D, Álvarez-Torres MDM, Juan-Albarracín J, Chelebian E, Rovira A, Acosta CA, Pineda J, Oleaga L, Mollá-Olmos E, Filice S, Due-Tønnessen P, Meling TR, Emblem KE, García-Gómez JM (2020)
MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas
Eur Radiol, 31 (3), 1738-1747
DOI 10.1007/s00330-020-07297-4, PubMed 33001310

Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT (2020)
Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients
Neurooncol Adv, 2 (1), vdaa157
DOI 10.1093/noajnl/vdaa157, PubMed 33392506

Guldvik IJ, Zuber V, Braadland PR, Grytli HH, Ramberg H, Lilleby W, Thiede B, Zucknick M, Saatcioglu F, Gislefoss R, Kvåle R, George A, Grönberg H, Wiklund F, Neal DE, Gnanapragasam VJ, Taskén KA, Mills IG (2020)
Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification
Eur Urol Open Sci, 21, 51-60
DOI 10.1016/j.euros.2020.08.007, PubMed 34337468

Halvorsen AR, Haugen MH, Öjlert ÅK, Lund-Iversen M, Jørgensen L, Solberg S, Mælandsmo GM, Brustugun OT, Helland Å (2020)
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients
Front Oncol, 10, 590755
DOI 10.3389/fonc.2020.590755, PubMed 33324562

Hillestad T, Hompland T, Fjeldbo CS, Skingen VE, Salberg UB, Aarnes EK, Nilsen A, Lund KV, Evensen TS, Kristensen GB, Stokke T, Lyng H (2020)
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Cancer Res, 80 (18), 3993-4003
DOI 10.1158/0008-5472.CAN-20-0950, PubMed 32606004

Hovden IT, Geier OM, Digernes I, Fuster-Garcia E, Løvland G, Vik-Mo E, Meling TR, Emblem KE (2020)
The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma
Eur J Radiol, 132, 109278
DOI 10.1016/j.ejrad.2020.109278, PubMed 33010685

Haakensen VD, Khadse A, Sandhu V, Halvorsen AR, Solberg SK, Jørgensen LH, Brustugun OT, Kure EH, Helland Å (2020)
Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy
Int J Cancer, 147 (10), 2957-2966
DOI 10.1002/ijc.33121, PubMed 32468587

Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Mol Oncol, 14 (5), 1016-1027
DOI 10.1002/1878-0261.12668, PubMed 32171051

Ji X, Lin L, Shen S, Dong X, Chen C, Li Y, Zhu Y, Huang H, Chen J, Chen X, Wei L, He J, Duan W, Su L, Jiang Y, Fan J, Guan J, You D, Shafer A, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M et al. (2020)
Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients
Mol Oncol, 14 (11), 2759-2774
DOI 10.1002/1878-0261.12785, PubMed 33448640

K Jensen NB, Pötter R, Spampinato S, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Wiebe E, Cooper R, Van der Steen-Banasik E, Van Limbergen E, Sundset M, Pieters BR, Nout RA, Kirisits C, Kirchheiner K, Tanderup K, EMBRACE Collaborative Group (2020)
Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients After Radiochemotherapy With Image Guided Adaptive Brachytherapy in the EMBRACE I Study
Int J Radiat Oncol Biol Phys, 109 (3), 688-700
DOI 10.1016/j.ijrobp.2020.10.006, PubMed 33068689

Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO (2020)
A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061630, PubMed 32575464

Knoth J, Pötter R, Jürgenliemk-Schulz IM, Haie-Meder C, Fokdal L, Sturdza A, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Wiebe E, Rai B, Cooper R, van der Steen-Banasik E, van Limbergen E, Pieters BR, Sundset M, Tan LT, Nout RA, Tanderup K, Kirisits C, Nesvacil N, Lindegaard JC, Schmid MP (2020)
Clinical and imaging findings in cervical cancer and their impact on FIGO and TNM staging - An analysis from the EMBRACE study
Gynecol Oncol, 159 (1), 136-141
DOI 10.1016/j.ygyno.2020.07.007, PubMed 32798000

Kværner AS, Harnæs H, Alavi DH, Bärebring L, Henriksen HB, Guren MG, Lauritzen PM, Eggesbø HB, Wiedswang G, Smeland S, Blomhoff R (2020)
Should calculation of chemotherapy dosage for bowel cancer be based on body composition?
Tidsskr Nor Laegeforen, 140 (8)
DOI 10.4045/tidsskr.19.0769, PubMed 32463187

Landsverk HB, Sandquist LE, Bay LTE, Steurer B, Campsteijn C, Landsverk OJB, Marteijn JA, Petermann E, Trinkle-Mulcahy L, Syljuåsen RG (2020)
WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
Cell Rep, 33 (9), 108469
DOI 10.1016/j.celrep.2020.108469, PubMed 33264625

Larsson C, Groote I, Vardal J, Kleppestø M, Odland A, Brandal P, Due-Tønnessen P, Holme SS, Hope TR, Meling TR, Fosse E, Emblem KE, Bjørnerud A (2020)
Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy
Magn Reson Imaging, 68, 106-112
DOI 10.1016/j.mri.2020.01.012, PubMed 32004711

Latysheva A, Geier OM, Hope TR, Brunetti M, Micci F, Vik-Mo EO, Emblem KE, Server A (2020)
Diagnostic utility of Restriction Spectrum Imaging in the characterization of the peritumoral brain zone in glioblastoma: Analysis of overall and progression-free survival
Eur J Radiol, 132, 109289
DOI 10.1016/j.ejrad.2020.109289, PubMed 33002815

Leone JP, Emblem KE, Weitz M, Gelman RS, Schneider BP, Freedman RA, Younger J, Pinho MC, Sorensen AG, Gerstner ER, Harris G, Krop IE, Morganstern D, Sohl J, Hu J, Kasparian E, Winer EP, Lin NU (2020)
Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases
Breast Cancer Res, 22 (1), 131
DOI 10.1186/s13058-020-01372-w, PubMed 33256829

Lundar T, Due-Tønnessen BJ, Frič R, Brandal P, Due-Tønnessen P (2020)
Adult outcome after treatment of pediatric posterior fossa ependymoma: long-term follow-up of a single consecutive institutional series of 22 patients with more than 5 years of survival
J Neurosurg Pediatr, 26 (1), 22-26
DOI 10.3171/2020.1.PEDS19700, PubMed 32217795

Lundar T, Due-Tønnessen BJ, Frič R, Brandal P, Stensvold E, Due-Tønnessen P (2020)
Outcomes in adulthood after neurosurgical treatment of brain tumors in the first 3 years of life: long-term follow-up of a single consecutive institutional series of 97 patients
Childs Nerv Syst, 37 (2), 427-433
DOI 10.1007/s00381-020-04859-1, PubMed 32814984

Marijnen CAM, Peters FP, Rödel C, Bujko K, Haustermans K, Fokas E, Glynne-Jones R, Valentini V, Spindler KG, Guren MG, Maingon P, Calvo FA, Pares O, Glimelius B, Sebag-Montefiore D (2020)
International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic
Radiother Oncol, 148, 213-215
DOI 10.1016/j.radonc.2020.03.039, PubMed 32342861

Nilsen LB, Digernes I, Grøvik E, Saxhaug C, Latysheva A, Geier O, Breivik B, Sætre DO, Jacobsen KD, Helland Å, Emblem KE (2020)
Responses in the diffusivity and vascular function of the irradiated normal brain are seen up until 18 months following SRS of brain metastases
Neurooncol Adv, 2 (1), vdaa028
DOI 10.1093/noajnl/vdaa028, PubMed 32642687

Pilleron S, Charvat H, Araghi M, Arnold M, Fidler-Benaoudia MM, Bardot A, Grønlie Guren M, Tervonen H, Little A, O'Connell DL, Gavin A, De P, Aagard Thomsen L, Møller B, Jackson C, Bucher O, Walsh PM, Vernon S, Bray F, Soerjomataram I (2020)
Age disparities in stage-specific colon cancer survival across seven countries: An International Cancer Benchmarking Partnership SURVMARK-2 population-based study
Int J Cancer, 148 (7), 1575-1585
DOI 10.1002/ijc.33326, PubMed 33006395

Rahman MA, Brekke J, Arnesen V, Hannisdal MH, Navarro AG, Waha A, Herfindal L, Rygh CB, Bratland E, Brandal P, Haasz J, Oltedal L, Miletic H, Lundervold A, Lie SA, Goplen D, Chekenya M (2020)
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study
Immun Inflamm Dis, 8 (3), 342-359
DOI 10.1002/iid3.315, PubMed 32578964

Rao S, Sclafani F, Eng C, Adams RA, Guren MG, Sebag-Montefiore D, Benson A, Bryant A, Peckitt C, Segelov E, Roy A, Seymour MT, Welch J, Saunders MP, Muirhead R, O'Dwyer P, Bridgewater J, Bhide S, Glynne-Jones R, Arnold D, Cunningham D (2020)
International Rare Cancers Initiative Multicenter Randomized Phase II Trial of Cisplatin and Fluorouracil Versus Carboplatin and Paclitaxel in Advanced Anal Cancer: InterAAct
J Clin Oncol, 38 (22), 2510-2518
DOI 10.1200/JCO.19.03266, PubMed 32530769

Ryg U, Lilleby W, Hole KH, Lund-Iversen M, Switlyk MD (2020)
Local Recurrence of Prostate Cancer to the Intersphincteric Space: A Case Report
Urology, 140, 18-21
DOI 10.1016/j.urology.2020.03.009, PubMed 32199872

Samnoy AT, Ytre-Hauge KS, Malinen E, Tran L, Rosenfeld A, Povoli M, Kok A, Summanwar A, Rohrich D (2020)
Microdosimetry with a 3D silicon on insulator (SOI) detector in a low energy proton beamline
Radiat. Phys. Chem., 176, 109078
DOI 10.1016/j.radphyschem.2020.109078

Sande EPS, Acosta Roa AM, Hellebust TP (2020)
Dose deviations induced by respiratory motion for radiotherapy of lung tumors: Impact of CT reconstruction, plan complexity, and fraction size
J Appl Clin Med Phys, 21 (4), 68-79
DOI 10.1002/acm2.12847, PubMed 32166850

Serban M, Kirisits C, de Leeuw A, Pötter R, Jürgenliemk-Schulz I, Nesvacil N, Swamidas J, Hudej R, Lowe G, Hellebust TP, Menon G, Oinam A, Bownes P, Oosterveld B, De Brabandere M, Koedooder K, Langeland Marthinsen AB, Whitney D, Lindegaard J, Tanderup K, EMBRACE Collaborative Group (2020)
Ring Versus Ovoids and Intracavitary Versus Intracavitary-Interstitial Applicators in Cervical Cancer Brachytherapy: Results From the EMBRACE I Study
Int J Radiat Oncol Biol Phys, 106 (5), 1052-1062
DOI 10.1016/j.ijrobp.2019.12.019, PubMed 32007365

Siebert FA, Kirisits C, Hellebust TP, Baltas D, Verhaegen F, Camps S, Pieters B, Kovács G, Thomadsen B (2020)
GEC-ESTRO/ACROP recommendations for quality assurance of ultrasound imaging in brachytherapy
Radiother Oncol, 148, 51-56
DOI 10.1016/j.radonc.2020.02.024, PubMed 32335363

Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A (2020)
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
EBioMedicine, 59, 102923
DOI 10.1016/j.ebiom.2020.102923, PubMed 32799124

Spampinato S, Fokdal LU, Pötter R, Haie-Meder C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, van der Steen-Banasik E, Van Limbergen E, Sundset M, Westerveld H, Nout RA, Jensen NBK, Kirisits C, Kirchheiner K, Tanderup K, EMBRACE Collaborative Group (2020)
Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis
Radiother Oncol, 158, 300-308
DOI 10.1016/j.radonc.2020.10.003, PubMed 33065183

Stadskleiv K, Stensvold E, Stokka K, Bechensteen AG, Brandal P (2020)
Neuropsychological functioning in survivors of childhood medulloblastoma/CNS-PNET: The role of secondary medical complications
Clin Neuropsychol, 36 (3), 600-625
DOI 10.1080/13854046.2020.1794045, PubMed 32729777

Stankovic B, Aamodt H, Bjørhovde HAK, Müller E, Hammarström C, Brustugun OT, Helland Å, Øynebråten I, Corthay A (2020)
The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases
Scand J Immunol, 92 (2), e12893
DOI 10.1111/sji.12893, PubMed 32433774

Stensvold E, Stadskleiv K, Myklebust TÅ, Wesenberg F, Helseth E, Bechensteen AG, Brandal P (2020)
Unmet rehabilitation needs in 86% of Norwegian paediatric embryonal brain tumour survivors
Acta Paediatr, 109 (9), 1875-1886
DOI 10.1111/apa.15188, PubMed 31977119

Tan LT, Tanderup K, Kirisits C, Mahantshetty U, Swamidas J, Jürgenliemk-Schulz I, Lindegaard J, de Leeuw A, Nesvacil N, Assenholt M, Berger D, Diendorfer T, Dimopoulos J, Duke S, Ecker S, Fokdal L, Hellebust T, Jensen N, Kirchheiner K, Nout R, Petric P, Schmid M, Seppenwoolde Y, Sturdza A, Van Limbergen E et al. (2020)
Education and training for image-guided adaptive brachytherapy for cervix cancer-The (GEC)-ESTRO/EMBRACE perspective
Brachytherapy, 19 (6), 827-836
DOI 10.1016/j.brachy.2020.06.012, PubMed 32811761

Umu SU, Langseth H, Keller A, Meese E, Helland Å, Lyle R, Rounge TB (2020)
A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis
Mol Oncol, 14 (2), 235-247
DOI 10.1002/1878-0261.12620, PubMed 31851411

van den Boomen M, Manhard MK, Snel GJH, Han S, Emblem KE, Slart RHJA, Sosnovik DE, Catana C, Rosen BR, Prakken NHJ, Nguyen CT, Borra RJH, Setsompop K (2020)
Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging
Radiology, 294 (3), 538-545
DOI 10.1148/radiol.2020191845, PubMed 31961241

van Houdt PJ, Kallehauge JF, Tanderup K, Nout R, Zaletelj M, Tadic T, van Kesteren ZJ, van den Berg CAT, Georg D, Côté JC, Levesque IR, Swamidas J, Malinen E, Telliskivi S, Brynolfsson P, Mahmood F, van der Heide UA, EMBRACE Collaborative Group (2020)
Phantom-based quality assurance for multicenter quantitative MRI in locally advanced cervical cancer
Radiother Oncol, 153, 114-121
DOI 10.1016/j.radonc.2020.09.013, PubMed 32931890

Vittrup AS, Tanderup K, Bentzen SM, Jensen NBK, Spampinato S, Fokdal LU, Lindegaard JC, Sturdza A, Schmid M, Segedin B, Jürgenliemk-Schulz IM, Bruheim K, Mahantshetty U, Haie-Meder C, Rai B, Cooper R, van der Steen-Banasik E, Sundset M, Huang F, Nout RA, Villafranca E, Van Limbergen E, Pieters BR, Tan LT, Lutgens LCHW et al. (2020)
Persistence of Late Substantial Patient-Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study
Int J Radiat Oncol Biol Phys, 109 (1), 161-173
DOI 10.1016/j.ijrobp.2020.08.044, PubMed 32853710

Zhang R, Chen C, Dong X, Shen S, Lai L, He J, You D, Lin L, Zhu Y, Huang H, Chen J, Wei L, Chen X, Li Y, Guo Y, Duan W, Liu L, Su L, Shafer A, Fleischer T, Moksnes Bjaanæs M, Karlsson A, Planck M, Wang R, Staaf J et al. (2020)
Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects
Chest, 158 (2), 808-819
DOI 10.1016/j.chest.2020.01.048, PubMed 32113923

Öjlert ÅK, Nebdal D, Lund-Iversen M, Åstrøm Ellefsen R, Brustugun OT, Gran JM, Halvorsen AR, Helland Å (2020)
Immune checkpoint blockade in the treatment of advanced non-small cell lung cancer - predictors of response and impact of previous radiotherapy
Acta Oncol, 60 (2), 149-156
DOI 10.1080/0284186X.2020.1854851, PubMed 33356733

Publications 2019

Abravan A, Eide HA, Løndalen AM, Helland Å, Malinen E (2019)
Mapping Bone Marrow Response in the Vertebral Column by Positron Emission Tomography Following Radiotherapy and Erlotinib Therapy of Lung Cancer
Mol Imaging Biol, 21 (2), 391-398
DOI 10.1007/s11307-018-1226-7, PubMed 29916117

Alluri SR, Pitman KE, Malinen E, Riss PJ (2019)
Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[¹⁸ F]fluoro-L-amino suberate
J Labelled Comp Radiopharm, 63 (1), 6-14
DOI 10.1002/jlcr.3814, PubMed 31697846

Araghi M, Soerjomataram I, Bardot A, Ferlay J, Cabasag CJ, Morrison DS, De P, Tervonen H, Walsh PM, Bucher O, Engholm G, Jackson C, McClure C, Woods RR, Saint-Jacques N, Morgan E, Ransom D, Thursfield V, Møller B, Leonfellner S, Guren MG, Bray F, Arnold M (2019)
Changes in colorectal cancer incidence in seven high-income countries: a population-based study
Lancet Gastroenterol Hepatol, 4 (7), 511-518
DOI 10.1016/S2468-1253(19)30147-5, PubMed 31105047

Bains SJ, Niehusmann PF, Meling TR, Saxhaug C, Züchner M, Brandal P (2019)
Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease-a case report and literature review
Acta Neurochir (Wien), 161 (2), 343-349
DOI 10.1007/s00701-019-03800-z, PubMed 30652202

Ben-Aharon I, Goshen-Lago T, Fontana E, Smyth E, Guren M, Caballero C, Lordick F (2019)
Social networks for young patients with cancer: the time for system agility
Lancet Oncol, 20 (6), 765
DOI 10.1016/S1470-2045(19)30346-8, PubMed 31162090

Berger T, Seppenwoolde Y, Pötter R, Assenholt MS, Lindegaard JC, Nout RA, de Leeuw A, Jürgenliemk-Schulz I, Tan LT, Georg D, Kirisits C, Dumas I, Nesvacil N, Swamidas J, Hudej R, Lowe G, Hellebust TP, Menon G, Fokdal L, Tanderup K, EMBRACE Collaborative Group (2019)
Importance of Technique, Target Selection, Contouring, Dose Prescription, and Dose-Planning in External Beam Radiation Therapy for Cervical Cancer: Evolution of Practice From EMBRACE-I to II
Int J Radiat Oncol Biol Phys, 104 (4), 885-894
DOI 10.1016/j.ijrobp.2019.03.020, PubMed 30904706

Bergholtz H, Lien TG, Ursin G, Holmen MM, Helland Å, Sørlie T, Haakensen VD (2019)
A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue
J Mammary Gland Biol Neoplasia, 24 (2), 163-175
DOI 10.1007/s10911-018-09423-x, PubMed 30613869

Bjune K, Høyer E, Schanke AK, Brandal P (2019)
Need for rehabilitation after brain tumour
Tidsskr Nor Laegeforen, 139 (10)
DOI 10.4045/tidsskr.19.0268, PubMed 31238657

Bogsrud TV, Londalen A, Brandal P, Leske H, Panagopoulos I, Borghammer P, Bach-Gansmo T (2019)
18F-Fluciclovine PET/CT in Suspected Residual or Recurrent High-Grade Glioma
Clin Nucl Med, 44 (8), 605-611
DOI 10.1097/RLU.0000000000002641, PubMed 31274605

Brunsell TH, Cengija V, Sveen A, Bjørnbeth BA, Røsok BI, Brudvik KW, Guren MG, Lothe RA, Abildgaard A, Nesbakken A (2019)
Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
Eur J Surg Oncol, 45 (12), 2340-2346
DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075

Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA (2019)
High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
Clin Colorectal Cancer, 19 (1), e26-e47
DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351

Del Mar Álvarez-Torres M, Juan-Albarracín J, Fuster-Garcia E, Bellvís-Bataller F, Lorente D, Reynés G, Font de Mora J, Aparici-Robles F, Botella C, Muñoz-Langa J, Faubel R, Asensio-Cuesta S, García-Ferrando GA, Chelebian E, Auger C, Pineda J, Rovira A, Oleaga L, Mollà-Olmos E, Revert AJ, Tshibanda L, Crisi G, Emblem KE, Martin D, Due-Tønnessen P et al. (2019)
Robust association between vascular habitats and patient prognosis in glioblastoma: An international multicenter study
J Magn Reson Imaging, 51 (5), 1478-1486
DOI 10.1002/jmri.26958, PubMed 31654541

Dong X, Zhang R, He J, Lai L, Alolga RN, Shen S, Zhu Y, You D, Lin L, Chen C, Zhao Y, Duan W, Su L, Shafer A, Salama M, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Wang R, Staaf J, Helland Å, Esteller M, Wei Y, Chen F et al. (2019)
Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma
Aging (Albany NY), 11 (16), 6312-6335
DOI 10.18632/aging.102189, PubMed 31434796

Due-Tønnessen P, Pinho MC, Emblem KE, Hald JK, Kanoto M, Abildgaard A, Sederevicius D, Groote IR, Rapalino O, Bjørnerud A (2019)
The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma
Sci Rep, 9 (1), 19898
DOI 10.1038/s41598-019-56333-x, PubMed 31882644

Gerstner ER, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T (2019)
Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma
Clin Cancer Res, 26 (1), 206-212
DOI 10.1158/1078-0432.CCR-19-1739, PubMed 31558474

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2019)
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929

Guren MG (2019)
The global challenge of colorectal cancer
Lancet Gastroenterol Hepatol, 4 (12), 894-895
DOI 10.1016/S2468-1253(19)30329-2, PubMed 31648973

Halvorsen AR, Ragle Aure M, Õjlert ÅK, Brustugun OT, Solberg S, Nebdal D, Helland Å (2019)
Identification of microRNAs involved in pathways which characterize the expression subtypes of NSCLC
Mol Oncol, 13 (12), 2604-2615
DOI 10.1002/1878-0261.12571, PubMed 31505091

Hauge S, Macurek L, Syljuåsen RG (2019)
p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775
Cell Cycle, 18 (8), 834-847
DOI 10.1080/15384101.2019.1593649, PubMed 30943845

Jonsson M, Fjeldbo CS, Holm R, Stokke T, Kristensen GB, Lyng H (2019)
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer
Neoplasia, 21 (4), 353-362
DOI 10.1016/j.neo.2019.01.002, PubMed 30856376

Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG (2019)
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
Nucleic Acids Res, 47 (4), 1797-1813
DOI 10.1093/nar/gky1233, PubMed 30541148

Latysheva A, Emblem KE, Brandal P, Vik-Mo EO, Pahnke J, Røysland K, Hald JK, Server A (2019)
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology, 61 (5), 545-555
DOI 10.1007/s00234-019-02173-5, PubMed 30712139

Lilleby O, Hernes E, Lilleby W (2019)
Metastatic-directed therapy using PSMA-PET/CT at PSA relapse
Urol Case Rep, 27, 100992
DOI 10.1016/j.eucr.2019.100992, PubMed 31453108

Lundar T, Due-Tønnessen BJ, Frič R, Brandal P, Stensvold E, Due-Tønnessen P (2019)
Adult outcome after neurosurgical treatment of brain tumours in the first year of life: long-term follow-up of a single consecutive institutional series of 34 patients
Acta Neurochir (Wien), 161 (9), 1793-1798
DOI 10.1007/s00701-019-04014-z, PubMed 31309304

Lundar T, Due-Tønnessen BJ, Frič R, Krossnes B, Brandal P, Stensvold E, Due-Tønnessen P (2019)
Neurosurgical treatment of pediatric pleomorphic xanthoastrocytomas: long-term follow-up of a single-institution, consecutive series of 12 patients
J Neurosurg Pediatr, 23 (4), 512-516
DOI 10.3171/2018.11.PEDS18449, PubMed 30738389

Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER (2019)
Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI
Sci Rep, 9 (1), 8721
DOI 10.1038/s41598-019-44365-2, PubMed 31197238

Moan JM, Amdal CD, Malinen E, Svestad JG, Bogsrud TV, Dale E (2019)
The prognostic role of 18F-fluorodeoxyglucose PET in head and neck cancer depends on HPV status
Radiother Oncol, 140, 54-61
DOI 10.1016/j.radonc.2019.05.019, PubMed 31177043

Nilsen A, Jonsson M, Aarnes EK, Kristensen GB, Lyng H (2019)
Reference MicroRNAs for RT-qPCR Assays in Cervical Cancer Patients and Their Application to Studies of HPV16 and Hypoxia Biomarkers
Transl Oncol, 12 (3), 576-584
DOI 10.1016/j.tranon.2018.12.010, PubMed 30660934

Nomden CN, Pötter R, de Leeuw AAC, Tanderup K, Lindegaard JC, Schmid MP, Fortin I, Haie-Meder C, Mahantshetty U, Hoskin P, Segedin B, Bruheim K, Rai B, Huang F, Cooper R, Van Der Steen Banasik E, Van Limbergen E, Jürgenliemk-Schulz IM, EMBRACE Collaborative Group (2019)
Nodal failure after chemo-radiation and MRI guided brachytherapy in cervical cancer: Patterns of failure in the EMBRACE study cohort
Radiother Oncol, 134, 185-190
DOI 10.1016/j.radonc.2019.02.007, PubMed 31005214

Nygård S, Lingjærde OC, Caldas C, Hovig E, Børresen-Dale AL, Helland Å, Haakensen VD (2019)
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995

Pitman KE, Alluri SR, Kristian A, Aarnes EK, Lyng H, Riss PJ, Malinen E (2019)
Influx rate of ¹⁸F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts
Eur J Nucl Med Mol Imaging, 46 (10), 2190-2198
DOI 10.1007/s00259-019-04375-8, PubMed 31264167

Pitman KE, Bakke KM, Kristian A, Malinen E (2019)
Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist
Cancer Imaging, 19 (1), 88
DOI 10.1186/s40644-019-0280-y, PubMed 31856923

Rusten E, Rekstad BL, Undseth C, Klotz D, Hernes E, Guren MG, Malinen E (2019)
Anal cancer chemoradiotherapy outcome prediction using ¹⁸F-fluorodeoxyglucose positron emission tomography and clinicopathological factors
Br J Radiol, 92 (1097), 20181006
DOI 10.1259/bjr.20181006, PubMed 30810343

Rødland GE, Melhus K, Generalov R, Gilani S, Bertoni F, Dahle J, Syljuåsen RG, Patzke S (2019)
The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37-Targeted Radioimmunotherapy in Activated B Cell Like Diffuse Large B Cell Lymphoma Cell Lines
Front Oncol, 9, 1301
DOI 10.3389/fonc.2019.01301, PubMed 31850205

Röhrl K, Guren MG, Astrup GL, Småstuen MC, Rustøen T (2019)
High symptom burden is associated with impaired quality of life in colorectal cancer patients during chemotherapy:A prospective longitudinal study
Eur J Oncol Nurs, 44, 101679
DOI 10.1016/j.ejon.2019.101679, PubMed 31751848

Röhrl K, Guren MG, Småstuen MC, Rustøen T (2019)
Symptoms during chemotherapy in colorectal cancer patients
Support Care Cancer, 27 (8), 3007-3017
DOI 10.1007/s00520-018-4598-y, PubMed 30607676

Sandler KA, Cook RR, Ciezki JP, Ross AE, Pomerantz MM, Nguyen PL, Shaikh T, Tran PT, Stock RG, Merrick GS, Demanes DJ, Spratt DE, Abu-Isa EI, Wedde TB, Lilleby W, Krauss DJ, Shaw GK, Alam R, Reddy CA, Song DY, Klein EA, Stephenson AJ, Tosoian JJ, Hegde JV, Yoo SM et al. (2019)
Prostate-only Versus Whole-pelvis Radiation with or Without a Brachytherapy Boost for Gleason Grade Group 5 Prostate Cancer: A Retrospective Analysis
Eur Urol, 77 (1), 3-10
DOI 10.1016/j.eururo.2019.03.022, PubMed 30992160

Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK (2019)
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium
Nat Biomed Eng, 3 (3), 230-245
DOI 10.1038/s41551-018-0334-7, PubMed 30948807

Shao B, Bjaanæs MM, Helland Å, Schütte C, Conrad T (2019)
EMT network-based feature selection improves prognosis prediction in lung adenocarcinoma
PLoS One, 14 (1), e0204186
DOI 10.1371/journal.pone.0204186, PubMed 30703089

Smeby J, Sveen A, Bergsland CH, Eilertsen IA, Danielsen SA, Eide PW, Hektoen M, Guren MG, Nesbakken A, Bruun J, Lothe RA (2019)
Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
ESMO Open, 4 (3), e000523
DOI 10.1136/esmoopen-2019-000523, PubMed 31321083

Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
Oncogenesis, 8 (6), 35
DOI 10.1038/s41389-019-0141-3, PubMed 31092812

Solberg S, Nilssen Y, Brustugun OT, Grimsrud TK, Haram PM, Helbekkmo N, Helland Å, Hjelde HH, Jakobsen B, Møller B, Petersen M, Strand TE, Wahl SGF, Aanerud M, Fjellbirkeland L (2019)
Increase in curative treatment and survival of lung cancer in Norway 2001-2016
Eur J Epidemiol, 34 (10), 951-955
DOI 10.1007/s10654-019-00536-z, PubMed 31313073

Stankovic B, Bjørhovde HAK, Skarshaug R, Aamodt H, Frafjord A, Müller E, Hammarström C, Beraki K, Bækkevold ES, Woldbæk PR, Helland Å, Brustugun OT, Øynebråten I, Corthay A (2019)
Immune Cell Composition in Human Non-small Cell Lung Cancer
Front Immunol, 9, 3101
DOI 10.3389/fimmu.2018.03101, PubMed 30774636

Stensvold E, Myklebust TÅ, Cappelen J, Due-Tønnessen BJ, Due-Tønnessen P, Kepka A, Johannesen TB, Krossnes B, Lundar T, Maric S, Miletic H, Moholdt V, Myrmel KS, Nordberg T, Rydland J, Stokland T, Solem K, Solheim O, Torsvik I, Wikran GC, Zeller B, Wesenberg F, Bechensteen AG, Brandal P (2019)
Children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor in Norway from 1974 through 2013: Unexplainable regional differences in survival
Pediatr Blood Cancer, 66 (10), e27910
DOI 10.1002/pbc.27910, PubMed 31264356

Stokkevåg CH, Indelicato DJ, Herfarth K, Magelssen H, Evensen ME, Ugland M, Nordberg T, Nystad TA, Hægeland C, Alsaker MD, Ulven K, Dale JE, Engeseth GM, Boer CG, Toussaint L, Kornerup JS, Pettersen HES, Brydøy M, Brandal P, Muren LP (2019)
Normal tissue complication probability models in plan evaluation of children with brain tumors referred to proton therapy
Acta Oncol, 58 (10), 1416-1422
DOI 10.1080/0284186X.2019.1643496, PubMed 31364899

Swamidas J, Kirisits C, De Brabandere M, Hellebust TP, Siebert FA, Tanderup K (2019)
Image registration, contour propagation and dose accumulation of external beam and brachytherapy in gynecological radiotherapy
Radiother Oncol, 143, 1-11
DOI 10.1016/j.radonc.2019.08.023, PubMed 31564555

Switlyk MD, Salberg UB, Geier OM, Vlatkovic L, Lilleby W, Lyng H, Seierstad T (2019)
PTEN Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings
AJR Am J Roentgenol, 212 (6), 1206-1214
DOI 10.2214/AJR.18.20743, PubMed 30888866

Zhang R, Lai L, Dong X, He J, You D, Chen C, Lin L, Zhu Y, Huang H, Shen S, Wei L, Chen X, Guo Y, Liu L, Su L, Shafer A, Moran S, Fleischer T, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Wei Y et al. (2019)
SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic-smoking interaction analysis
Mol Oncol, 13 (5), 1235-1248
DOI 10.1002/1878-0261.12482, PubMed 30924596

Zhang R, Lai L, He J, Chen C, You D, Duan W, Dong X, Zhu Y, Lin L, Shen S, Guo Y, Su L, Shafer A, Moran S, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Wei Y, Chen F, Christiani DC (2019)
EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC
Epigenetics, 14 (2), 118-129
DOI 10.1080/15592294.2019.1573066, PubMed 30665327

Öjlert ÅK, Halvorsen AR, Nebdal D, Lund-Iversen M, Solberg S, Brustugun OT, Lingjaerde OC, Helland Å (2019)
The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery
Mol Oncol, 13 (5), 1166-1179
DOI 10.1002/1878-0261.12475, PubMed 30854794

Publications 2018

Angeli S, Emblem KE, Due-Tonnessen P, Stylianopoulos T (2018)
Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI
Neuroimage Clin, 20, 664-673
DOI 10.1016/j.nicl.2018.08.032, PubMed 30211003

Benitez Majano S, Di Girolamo C, Rachet B, Maringe C, Guren MG, Glimelius B, Iversen LH, Schnell EA, Lundqvist K, Christensen J, Morris M, Coleman MP, Walters S (2018)
Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study
Lancet Oncol, 20 (1), 74-87
DOI 10.1016/S1470-2045(18)30646-6, PubMed 30545752

Berg J, Halvorsen AR, Bengtson MB, Taskén KA, Mælandsmo GM, Yndestad A, Halvorsen B, Brustugun OT, Aukrust P, Ueland T, Helland Å (2018)
Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease
BMC Cancer, 18 (1), 739
DOI 10.1186/s12885-018-4659-0, PubMed 30005623

Brustugun OT, Grønberg BH, Fjellbirkeland L, Helbekkmo N, Aanerud M, Grimsrud TK, Helland Å, Møller B, Nilssen Y, Strand TE, Solberg SK (2018)
Substantial nation-wide improvement in lung cancer relative survival in Norway from 2000 to 2016
Lung Cancer, 122, 138-145
DOI 10.1016/j.lungcan.2018.06.003, PubMed 30032822

Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA (2018)
Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
Mol Oncol, 12 (9), 1639-1655
DOI 10.1002/1878-0261.12347, PubMed 29900672

Bøe CA, Håland TW, Boye E, Syljuåsen RG, Grallert B (2018)
A novel role for ATR/Rad3 in G1 phase
Sci Rep, 8 (1), 6880
DOI 10.1038/s41598-018-25238-6, PubMed 29720710

Claassen YHM, Vermeer NCA, Iversen LH, van Eycken E, Guren MG, Mroczkowski P, Martling A, Codina Cazador A, Johansson R, Vandendael T, Wibe A, Moller B, Lippert H, Rutten HJT, Portielje JEA, Liefers GJ, Holman FA, van de Velde CJH, Bastiaannet E (2018)
Treatment and survival of rectal cancer patients over the age of 80 years: a EURECCA international comparison
Br J Cancer, 119 (4), 517-522
DOI 10.1038/s41416-018-0215-6, PubMed 30057408

Dale E, Waldeland E (2018)
Proton therapy - a reality in Norway from 2023
Tidsskr Nor Laegeforen, 138 (13)
DOI 10.4045/tidsskr.18.0250, PubMed 30180494

de Lange C, Solberg R, Holtedahl JE, Tulipan A, Barlinn J, Trigg W, Wickstrøm T, Saugstad OD, Malinen E, Revheim ME (2018)
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs
Nucl Med Biol, 66, 49-57
DOI 10.1016/j.nucmedbio.2018.08.004, PubMed 30257223

Digernes I, Grøvik E, Nilsen LB, Saxhaug C, Geier O, Reitan E, Sætre DO, Breivik B, Reese T, Jacobsen KD, Helland Å, Emblem KE (2018)
Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery
Adv Radiat Oncol, 3 (4), 559-567
DOI 10.1016/j.adro.2018.05.005, PubMed 30370356

Eide HA, Knudtsen IS, Sandhu V, Løndalen AM, Halvorsen AR, Abravan A, Kure EH, Bogsrud TV, Brustugun OT, Kyte JA, Malinen E, Helland Å (2018)
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy
Adv Radiat Oncol, 3 (2), 130-138
DOI 10.1016/j.adro.2017.12.007, PubMed 29904737

Eide PK, Vatnehol SAS, Emblem KE, Ringstad G (2018)
Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes
Sci Rep, 8 (1), 7194
DOI 10.1038/s41598-018-25666-4, PubMed 29740121

Fokdal L, Tanderup K, Pötter R, Sturdza A, Kirchheiner K, Chargari C, Jürgenliemk-Schulz IM, Segedin B, Tan LT, Hoskin P, Mahantshetty U, Bruheim K, Rai B, Kirisits C, Lindegaard JC, EMBRACE Collaborative Group (2018)
Risk Factors for Ureteral Stricture After Radiochemotherapy Including Image Guided Adaptive Brachytherapy in Cervical Cancer: Results From the EMBRACE Studies
Int J Radiat Oncol Biol Phys, 103 (4), 887-894
DOI 10.1016/j.ijrobp.2018.11.006, PubMed 30419309

Gandara DR, von Pawel J, Mazieres J, Sullivan R, Helland Å, Han JY, Ponce Aix S, Rittmeyer A, Barlesi F, Kubo T, Park K, Goldschmidt J, Gandhi M, Yun C, Yu W, Matheny C, He P, Sandler A, Ballinger M, Fehrenbacher L (2018)
Atezolizumab Treatment Beyond Progression in Advanced NSCLC: Results From the Randomized, Phase III OAK Study
J Thorac Oncol, 13 (12), 1906-1918
DOI 10.1016/j.jtho.2018.08.2027, PubMed 30217492

George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Müller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, De Reynies A, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmüller J, Becker C, Nürnberg P, Achter V, Lang U, Schneider PM et al. (2018)
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
Nat Commun, 9 (1), 1048
DOI 10.1038/s41467-018-03099-x, PubMed 29535388

Guo Y, Zhang R, Shen S, Wei Y, Salama SM, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Su L, Zhu Z, Staaf J, Helland Å, Esteller M, Christiani DC (2018)
DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients
Cancer Epidemiol Biomarkers Prev, 27 (12), 1527-1535
DOI 10.1158/1055-9965.EPI-18-0454, PubMed 30185536

Guren MG, Aagnes B, Nygård M, Dahl O, Møller B (2018)
Rising Incidence and Improved Survival of Anal Squamous Cell Carcinoma in Norway, 1987-2016
Clin Colorectal Cancer, 18 (1), e96-e103
DOI 10.1016/j.clcc.2018.10.001, PubMed 30415990

Halvorsen AR, Sandhu V, Sprauten M, Flote VG, Kure EH, Brustugun OT, Helland Å (2018)
Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab
Acta Oncol, 57 (9), 1225-1231
DOI 10.1080/0284186X.2018.1465585, PubMed 29683761

Hayman J, Hole KH, Seierstad T, Perin J, DeWeese TL, Tran PT, Lilleby W (2018)
Local failure is a dominant mode of recurrence in locally advanced and clinical node positive prostate cancer patients treated with combined pelvic IMRT and androgen deprivation therapy
Urol Oncol, 37 (4), 289.e19-289.e26
DOI 10.1016/j.urolonc.2018.09.016, PubMed 30446451

Helland A (2018)
Groundbreaking basic research
Tidsskr. Nor. Laegeforen., 138 (20), 1905

Helland Å (2018)
Groundbreaking basic research
Tidsskr Nor Laegeforen, 138 (20)
DOI 10.4045/tidsskr.18.0802, PubMed 30539600

Hellebust TP (2018)
Place of modern imaging in brachytherapy planning
Cancer Radiother, 22 (4), 326-333
DOI 10.1016/j.canrad.2018.03.005, PubMed 29858136

Hompland T, Hole KH, Ragnum HB, Aarnes EK, Vlatkovic L, Lie AK, Patzke S, Brennhovd B, Seierstad T, Lyng H (2018)
Combined MR Imaging of Oxygen Consumption and Supply Reveals Tumor Hypoxia and Aggressiveness in Prostate Cancer Patients
Cancer Res, 78 (16), 4774-4785
DOI 10.1158/0008-5472.CAN-17-3806, PubMed 29945958

Johannessen LE, Brandal P, Myklebust TÅ, Heim S, Micci F, Panagopoulos I (2018)
MGMT Gene Promoter Methylation Status - Assessment of Two Pyrosequencing Kits and Three Methylation-specific PCR Methods for their Predictive Capacity in Glioblastomas
Cancer Genomics Proteomics, 15 (6), 437-446
DOI 10.21873/cgp.20102, PubMed 30343277

Kishan AU, Cook RR, Ciezki JP, Ross AE, Pomerantz MM, Nguyen PL, Shaikh T, Tran PT, Sandler KA, Stock RG, Merrick GS, Demanes DJ, Spratt DE, Abu-Isa EI, Wedde TB, Lilleby W, Krauss DJ, Shaw GK, Alam R, Reddy CA, Stephenson AJ, Klein EA, Song DY, Tosoian JJ, Hegde JV et al. (2018)
Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy Boost and Disease Progression and Mortality in Patients With Gleason Score 9-10 Prostate Cancer
JAMA, 319 (9), 896-905
DOI 10.1001/jama.2018.0587, PubMed 29509865

Lam KC, Vyshenska D, Hu J, Rodrigues RR, Nilsen A, Zielke RA, Brown NS, Aarnes EK, Sikora AE, Shulzhenko N, Lyng H, Morgun A (2018)
Transkingdom network reveals bacterial players associated with cervical cancer gene expression program
PeerJ, 6, e5590
DOI 10.7717/peerj.5590, PubMed 30294508

Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK (2018)
Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III
J Comput Assist Tomogr, 42 (5), 807-815
DOI 10.1097/RCT.0000000000000742, PubMed 29901512

Leibfarth S, Winter RM, Lyng H, Zips D, Thorwarth D (2018)
Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy
Clin Transl Radiat Oncol, 13, 29-37
DOI 10.1016/j.ctro.2018.09.002, PubMed 30294681

Lundar T, Due-Tønnessen BJ, Fric R, Egge A, Krossnes B, Due-Tønnessen P, Stensvold E, Brandal P (2018)
Neurosurgical treatment of gangliogliomas in children and adolescents: long-term follow-up of a single-institution series of 32 patients
Acta Neurochir (Wien), 160 (6), 1207-1214
DOI 10.1007/s00701-018-3550-8, PubMed 29680921

Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER (2018)
Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI
Sci Rep, 8 (1), 17062
DOI 10.1038/s41598-018-34820-x, PubMed 30459364

Meling TR, Latysheva A, Da Broi M, Jahr G, Holte H, Beiske K, Emblem KE (2018)
Is deep brain involvement in intracranial primary central nervous system lymphoma of importance for penetration of chemotherapeutic agents?
Neuroradiology, 60 (7), 703-713
DOI 10.1007/s00234-018-2038-9, PubMed 29804159

Mikalsen SG, Mikalsen LTG, Sandvik JA, Aarnes EK, Fenne S, Flatmark K, Lyng H, Edin NFJ, Pettersen EO (2018)
Low dose-rate irradiation with [³H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model
Acta Oncol, 57 (9), 1216-1224
DOI 10.1080/0284186X.2018.1457223, PubMed 29630428

Najjari Jamal D, Pötter R, Haie-Meder C, Lindegaard JC, Juergenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Wiebe E, Cooper R, Tanderup K, Kirchheiner K, EMBRACE collaborative group (2018)
Physician assessed and patient reported lower limb edema after definitive radio(chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: A report from the EMBRACE study
Radiother Oncol, 127 (3), 449-455
DOI 10.1016/j.radonc.2018.03.026, PubMed 29631933

Panagopoulos I, Gorunova L, Leske H, Niehusmann P, Johannessen LE, Staurseth J, Øino N, Meling TR, Heim S, Micci F, Brandal P (2018)
Pyrosequencing Analysis of MGMT Promoter Methylation in Meningioma
Cancer Genomics Proteomics, 15 (5), 379-385
DOI 10.21873/cgp.20096, PubMed 30194078

Pötter R, Tanderup K, Kirisits C, de Leeuw A, Kirchheiner K, Nout R, Tan LT, Haie-Meder C, Mahantshetty U, Segedin B, Hoskin P, Bruheim K, Rai B, Huang F, Van Limbergen E, Schmid M, Nesvacil N, Sturdza A, Fokdal L, Jensen NBK, Georg D, Assenholt M, Seppenwoolde Y, Nomden C, Fortin I et al. (2018)
The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies
Clin Transl Radiat Oncol, 9, 48-60
DOI 10.1016/j.ctro.2018.01.001, PubMed 29594251

Ringstad G, Valnes LM, Dale AM, Pripp AH, Vatnehol SS, Emblem KE, Mardal KA, Eide PK (2018)
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
JCI Insight, 3 (13)
DOI 10.1172/jci.insight.121537, PubMed 29997300

Rye IH, Trinh A, Saetersdal AB, Nebdal D, Lingjaerde OC, Almendro V, Polyak K, Børresen-Dale AL, Helland Å, Markowetz F, Russnes HG (2018)
Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors
Mol Oncol, 12 (11), 1838-1855
DOI 10.1002/1878-0261.12375, PubMed 30133130

Sandler KA, Cook RR, Ciezki JP, Ross AE, Pomerantz MM, Nguyen PL, Shaikh T, Tran PT, Stock RG, Merrick GS, Demanes DJ, Spratt DE, Abu-Isa EI, Wedde TB, Lilleby W, Krauss DJ, Shaw GK, Alam R, Reddy CA, Song DY, Klein EA, Stephenson AJ, Tosoian JJ, Hegde JV, Yoo SM et al. (2018)
Clinical Outcomes for Patients With Gleason Score 10 Prostate Adenocarcinoma: Results From a Multi-institutional Consortium Study
Int J Radiat Oncol Biol Phys, 101 (4), 883-888
DOI 10.1016/j.ijrobp.2018.03.060, PubMed 29976500

Serban M, Kirisits C, Pötter R, de Leeuw A, Nkiwane K, Dumas I, Nesvacil N, Swamidas J, Hudej R, Lowe G, Hellebust TP, Menon G, Oinam A, Bownes P, Oosterveld B, De Brabandere M, Koedooder K, Marthinsen ABL, Lindegaard J, Tanderup K, EMBRACE Collaborative Group (2018)
Isodose surface volumes in cervix cancer brachytherapy: Change of practice from standard (Point A) to individualized image guided adaptive (EMBRACE I) brachytherapy
Radiother Oncol, 129 (3), 567-574
DOI 10.1016/j.radonc.2018.09.002, PubMed 30243671

Shen S, Zhang R, Guo Y, Loehrer E, Wei Y, Zhu Y, Yuan Q, Moran S, Fleischer T, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Su L, Chen F, Christiani DC (2018)
A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer
Mol Oncol, 12 (6), 913-924
DOI 10.1002/1878-0261.12204, PubMed 29656435

Skjøtskift T, Evensen ME, Furre T, Moan JM, Amdal CD, Bogsrud TV, Malinen E, Dale E (2018)
Dose painting for re-irradiation of head and neck cancer
Acta Oncol, 57 (12), 1693-1699
DOI 10.1080/0284186X.2018.1512753, PubMed 30280623

Smeby J, Sveen A, Merok MA, Danielsen SA, Eilertsen IA, Guren MG, Dienstmann R, Nesbakken A, Lothe RA (2018)
CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer
Ann Oncol, 29 (5), 1227-1234
DOI 10.1093/annonc/mdy085, PubMed 29518181

Smet S, Pötter R, Haie-Meder C, Lindegaard JC, Schulz-Juergenliemk I, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, van Limbergen E, Tanderup K, Kirchheiner K, EMBRACE Collaborative Group (2018)
Fatigue, insomnia and hot flashes after definitive radiochemotherapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: An analysis from the EMBRACE study
Radiother Oncol, 127 (3), 440-448
DOI 10.1016/j.radonc.2018.03.009, PubMed 29627137

Stranne J, Brasso K, Brennhovd B, Johansson E, Jäderling F, Kouri M, Lilleby W, Meidahl Petersen P, Mirtti T, Pettersson A, Rannikko A, Thellenberg C, Akre O (2018)
SPCG-15: a prospective randomized study comparing primary radical prostatectomy and primary radiotherapy plus androgen deprivation therapy for locally advanced prostate cancer
Scand J Urol, 52 (5-6), 313-320
DOI 10.1080/21681805.2018.1520295, PubMed 30585526

Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I (2018)
N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome
Mol Oncol, 12 (6), 972-990
DOI 10.1002/1878-0261.12312, PubMed 29698574

Tulipan AJ, Hole KH, Vlatkovic L, Revheim ME, Reijnen JS, Willoch F, Seierstad T, Lilleby W (2018)
Localization of radio-recurrence within the prostate: anti-3-18F-FACBC PET/CT compared with multiparametric MRI using histopathology as reference standard
Acta Radiol, 60 (8), 1028-1038
DOI 10.1177/0284185118810977, PubMed 30379559

Tulipan AJ, Vlatkovic L, Malinen E, Brennhovd B, Hole KH, Lie AK, Ragnum HB, Revheim ME, Seierstad T (2018)
Comparison of time curves from dynamic ¹⁸F-fluciclovine positron emission tomography and dynamic contrast-enhanced magnetic resonance imaging for primary prostate carcinomas
Phys Imaging Radiat Oncol, 7, 51-57
DOI 10.1016/j.phro.2018.09.003, PubMed 33458405

Vermeer NCA, Claassen YHM, Derks MGM, Iversen LH, van Eycken E, Guren MG, Mroczkowski P, Martling A, Johansson R, Vandendael T, Wibe A, Moller B, Lippert H, Portielje JEA, Liefers GJ, Peeters KCMJ, van de Velde CJH, Bastiaannet E (2018)
Treatment and Survival of Patients with Colon Cancer Aged 80 Years and Older: A EURECCA International Comparison
Oncologist, 23 (8), 982-990
DOI 10.1634/theoncologist.2017-0551, PubMed 29567826

Wedde TB, Småstuen MC, Brabrand S, Fosså SD, Kaasa S, Tafjord G, Russnes KM, Hellebust TP, Lilleby W (2018)
Ten-year survival after High-Dose-Rate Brachytherapy combined with External Beam Radiation Therapy in high-risk prostate cancer: A comparison with the Norwegian SPCG-7 cohort
Radiother Oncol, 132, 211-217
DOI 10.1016/j.radonc.2018.10.013, PubMed 30389241

Wei Y, Liang J, Zhang R, Guo Y, Shen S, Su L, Lin X, Moran S, Helland Å, Bjaanæs MM, Karlsson A, Planck M, Esteller M, Fleischer T, Staaf J, Zhao Y, Chen F, Christiani DC (2018)
Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC
Clin Epigenetics, 10, 41
DOI 10.1186/s13148-018-0474-3, PubMed 29619118

Publications 2017

Abravan A, Eide HA, Knudtsen IS, Løndalen AM, Helland Å, Malinen E (2017)
Assessment of pulmonary ¹⁸F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib
Clin Transl Radiat Oncol, 4, 57-63
DOI 10.1016/j.ctro.2017.04.002, PubMed 29594209

Abravan A, Knudtsen IS, Eide HA, Løndalen AM, Helland Å, van Luijk P, Malinen E (2017)
A new method to assess pulmonary changes using ¹⁸F-fluoro-2-deoxyglucose positron emission tomography for lung cancer patients following radiotherapy
Acta Oncol, 56 (11), 1597-1603
DOI 10.1080/0284186X.2017.1349336, PubMed 28849707

Andronesi OC, Esmaeili M, Borra RJH, Emblem K, Gerstner ER, Pinho MC, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Ivy SP, Wen PY, Duda DG, Jain R, Rosen BR, Sorensen GA, Batchelor TT (2017)
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival
NPJ Precis Oncol, 1
DOI 10.1038/s41698-017-0020-3, PubMed 29202103

Arnesen MR, Hellebust TP, Malinen E (2017)
Impact of dose escalation and adaptive radiotherapy for cervical cancers on tumour shrinkage-a modelling study
Phys Med Biol, 62 (6), N107-N119
DOI 10.1088/1361-6560/aa5de2, PubMed 28151724

Astrup GL, Hofsø K, Bjordal K, Guren MG, Vistad I, Cooper B, Miaskowski C, Rustøen T (2017)
Patient factors and quality of life outcomes differ among four subgroups of oncology patients based on symptom occurrence
Acta Oncol, 56 (3), 462-470
DOI 10.1080/0284186X.2016.1273546, PubMed 28077018

Byskov CS, Nyvang L, Guren MG, Spindler KLG, Muren LP (2017)
The normal tissue sparing potential of an adaptive plan selection strategy for re-irradiation of recurrent rectal cancer
Phys. Imag. Radiat. Oncol., 3, 43-48
DOI 10.1016/j.phro.2017.09.001

Dahle TJ, Rykkelid AM, Stokkevåg CH, Mairani A, Görgen A, Edin NJ, Rørvik E, Fjæra LF, Malinen E, Ytre-Hauge KS (2017)
Monte Carlo simulations of a low energy proton beamline for radiobiological experiments
Acta Oncol, 56 (6), 779-786
DOI 10.1080/0284186X.2017.1289239, PubMed 28464743

Dannenfelser R, Nome M, Tahiri A, Ursini-Siegel J, Vollan HKM, Haakensen VD, Helland Å, Naume B, Caldas C, Børresen-Dale AL, Kristensen VN, Troyanskaya OG (2017)
Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity
Oncotarget, 8 (34), 57121-57133
DOI 10.18632/oncotarget.19078, PubMed 28915659

Digernes I, Bjørnerud A, Vatnehol SAS, Løvland G, Courivaud F, Vik-Mo E, Meling TR, Emblem KE (2017)
A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI
J Cereb Blood Flow Metab, 37 (6), 2237-2248
DOI 10.1177/0271678X17694187, PubMed 28273722

Fleischer T, Klajic J, Aure MR, Louhimo R, Pladsen AV, Ottestad L, Touleimat N, Laakso M, Halvorsen AR, Grenaker Alnæs GI, Riis ML, Helland Å, Hautaniemi S, Lønning PE, Naume B, Børresen-Dale AL, Tost J, Kristensen VN (2017)
DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival
Oncotarget, 8 (1), 1074-1082
DOI 10.18632/oncotarget.13718, PubMed 27911866

Halvorsen AR, Kristensen G, Embleton A, Adusei C, Barretina-Ginesta MP, Beale P, Helland Å (2017)
Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients
Dis Markers, 2017, 3098542
DOI 10.1155/2017/3098542, PubMed 28293063

Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T, Syljuåsen RG (2017)
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
DOI 10.18632/oncotarget.14089, PubMed 28030798

Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK (2017)
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708, PubMed 28973009

Johansen S, Norman MH, Dale E, Amdal CD, Furre T, Malinen E, Evensen JF (2017)
Patterns of local-regional recurrence after conformal and intensity-modulated radiotherapy for head and neck cancer
Radiat Oncol, 12 (1), 87
DOI 10.1186/s13014-017-0829-5, PubMed 28545588

Jåstad EO, Torheim T, Villeneuve KM, Kvaal K, Hole EO, Sagstuen E, Malinen E, Futsaether CM (2017)
In Quest of the Alanine R3 Radical: Multivariate EPR Spectral Analyses of X-Irradiated Alanine in the Solid State
J Phys Chem A, 121 (38), 7139-7147
DOI 10.1021/acs.jpca.7b06447, PubMed 28829916

Kristian A, Holtedahl JE, Torheim T, Futsaether C, Hernes E, Engebraaten O, Mælandsmo GM, Malinen E (2017)
Dynamic 2-Deoxy-2-[¹⁸F]Fluoro-D-Glucose Positron Emission Tomography for Chemotherapy Response Monitoring of Breast Cancer Xenografts
Mol Imaging Biol, 19 (2), 271-279
DOI 10.1007/s11307-016-0998-x, PubMed 27541026

Labori KJ, Guren MG, Brudvik KW, Røsok BI, Waage A, Nesbakken A, Larsen S, Dueland S, Edwin B, Bjørnbeth BA (2017)
Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival
Colorectal Dis, 19 (8), 731-738
DOI 10.1111/codi.13622, PubMed 28181384

Leske H, Brandal P, Rushing EJ, Niehusmann P (2017)
IDH-mutant giant cell glioblastoma: A neglected tumor variant?
Clin Neuropathol, 36 (6), 293-295
DOI 10.5414/NP301054, PubMed 29035191

Li AN, Andersen E, Lervag C, Julin CH, Lyng H, Hellebust TP, Malinen E (2017)
Dynamic contrast enhanced magnetic resonance imaging for hypoxia mapping and potential for brachytherapy targeting
Phys. Imag. Radiat. Oncol., 2, 1-6
DOI 10.1016/j.phro.2017.03.002

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2017)
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
DOI 10.18632/oncotarget.14800, PubMed 28179591

Lilleby W, Gaudernack G, Brunsvig PF, Vlatkovic L, Schulz M, Mills K, Hole KH, Inderberg EM (2017)
Phase I/IIa clinical trial of a novel hTERT peptide vaccine in men with metastatic hormone-naive prostate cancer
Cancer Immunol Immunother, 66 (7), 891-901
DOI 10.1007/s00262-017-1994-y, PubMed 28391357

Lyng H, Malinen E (2017)
Hypoxia in cervical cancer: from biology to imaging
Clin Transl Imaging, 5 (4), 373-388
DOI 10.1007/s40336-017-0238-7, PubMed 28804704

Malinen E, Hysing LB, Waldeland E, Muren LP (2017)
Bridging imaging and therapy: the role of medical physics in development of precision cancer care
Acta Oncol, 56 (6), 757-760
DOI 10.1080/0284186X.2017.1316869, PubMed 28464737

McGowan M, Kleinberg L, Halvorsen AR, Helland Å, Brustugun OT (2017)
NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors
Genes Cancer, 8 (3-4), 497-504
DOI 10.18632/genesandcancer.136, PubMed 28680534

Mikalsen LTG, Arnesen MR, Bogsrud TV, Dale E, Stokke C (2017)
Combining radioiodine and external beam radiation therapy: the potential of integrated treatment planning for differentiated thyroid cancer
Acta Oncol, 56 (6), 894-897
DOI 10.1080/0284186X.2017.1286384, PubMed 28464741

Planchard D, Smit EF, Groen HJM, Mazieres J, Besse B, Helland Å, Giannone V, D'Amelio AM, Zhang P, Mookerjee B, Johnson BE (2017)
Dabrafenib plus trametinib in patients with previously untreated BRAF^V600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial
Lancet Oncol, 18 (10), 1307-1316
DOI 10.1016/S1470-2045(17)30679-4, PubMed 28919011

Ringstad G, Lindstrøm EK, Vatnehol SAS, Mardal KA, Emblem KE, Eide PK (2017)
Non-invasive assessment of pulsatile intracranial pressure with phase-contrast magnetic resonance imaging
PLoS One, 12 (11), e0188896
DOI 10.1371/journal.pone.0188896, PubMed 29190788

Rusten E, Rekstad BL, Undseth C, Al-Haidari G, Hanekamp B, Hernes E, Hellebust TP, Malinen E, Guren MG (2017)
Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography
Radiat Oncol, 12 (1), 147
DOI 10.1186/s13014-017-0883-z, PubMed 28874205

Sodergren SC, Johnson CD, Gilbert A, Tomaszewski KA, Chu W, Chung HT, Dennis K, Desideri I, Glynne-Jones R, Grønlie Guren M, Kardamakis D, Nugent K, Schmidt H, Sebag-Montefiore D, Vassiliou V, EORTC Quality of Life Group (2017)
Phase I-III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer
Radiother Oncol, 126 (2), 222-228
DOI 10.1016/j.radonc.2017.11.018, PubMed 29217122

Stensvold E, Krossnes BK, Lundar T, Due-Tønnessen BJ, Frič R, Due-Tønnessen P, Bechensteen AG, Myklebust TÅ, Johannesen TB, Brandal P (2017)
Outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS-PNET) - a retrospective analysis spanning 40 years of treatment
Acta Oncol, 56 (5), 698-705
DOI 10.1080/0284186X.2017.1301679, PubMed 28325133

Thomsen M, Guren MG, Skovlund E, Glimelius B, Hjermstad MJ, Johansen JS, Kure E, Sorbye H, Pfeiffer P, Christoffersen T, Guren TK, Tveit KM (2017)
Health-related quality of life in patients with metastatic colorectal cancer, association with systemic inflammatory response and RAS and BRAF mutation status
Eur J Cancer, 81, 26-35
DOI 10.1016/j.ejca.2017.04.026, PubMed 28595137

Torheim T, Malinen E, Hole KH, Lund KV, Indahl UG, Lyng H, Kvaal K, Futsaether CM (2017)
Autodelineation of cervical cancers using multiparametric magnetic resonance imaging and machine learning
Acta Oncol, 56 (6), 806-812
DOI 10.1080/0284186X.2017.1285499, PubMed 28464746

Åsli LM, Johannesen TB, Myklebust TÅ, Møller B, Eriksen MT, Guren MG (2017)
Preoperative chemoradiotherapy for rectal cancer and impact on outcomes - A population-based study
Radiother Oncol, 123 (3), 446-453
DOI 10.1016/j.radonc.2017.04.012, PubMed 28483302

Publications 2016

Arnesen MR, Rekstad BL, Stokke C, Bruheim K, Løndalen AM, Hellebust TP, Malinen E (2016)
Short-course PET based simultaneous integrated boost for locally advanced cervical cancer
Radiat Oncol, 11, 39
DOI 10.1186/s13014-016-0612-z, PubMed 26968827

Cameron MG, Kersten C, Vistad I, van Helvoirt R, Weyde K, Undseth C, Mjaaland I, Skovlund E, Fosså SD, Guren MG (2016)
Palliative pelvic radiotherapy for symptomatic rectal cancer - a prospective multicenter study
Acta Oncol, 55 (12), 1400-1407
DOI 10.1080/0284186X.2016.1191666, PubMed 27332723

Dale E, Moan JM, Osnes TA, Bogsrud TV (2016)
Cervical lymph node metastases of squamous cell carcinoma of unknown origin: the diagnostic value of FDG PET/CT and clinical outcome
Eur Arch Otorhinolaryngol, 274 (2), 1015-1019
DOI 10.1007/s00405-016-4318-5, PubMed 27671150

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis J et al. (2016)
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Nat Genet, 48 (4), 374-86
DOI 10.1038/ng.3521, PubMed 26928228

Eide HA, Halvorsen AR, Bjaanæs MM, Piri H, Holm R, Solberg S, Jørgensen L, Brustugun OT, Kiserud CE, Helland Å (2016)
The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes
BMC Cancer, 16, 71
DOI 10.1186/s12885-016-2104-9, PubMed 26858029

Eide HA, Halvorsen AR, Sandhu V, Fåne A, Berg J, Haakensen VD, Kure EH, Brustugun OT, Kiserud CE, Kyte JA, Helland Å (2016)
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Clin Transl Immunology, 5 (11), e109
DOI 10.1038/cti.2016.65, PubMed 27990285

Emblem KE, Jain RK (2016)
Improving treatment of liver metastases by targeting nonangiogenic mechanisms
Nat Med, 22 (11), 1209-1210
DOI 10.1038/nm.4228, PubMed 27824818

Espinoza JA, Jabeen S, Batra R, Papaleo E, Haakensen V, Timmermans Wielenga V, Møller Talman ML, Brunner N, Børresen-Dale AL, Gromov P, Helland Å, Kristensen VN, Gromova I (2016)
Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics
Oncoimmunology, 5 (12), e1248015
DOI 10.1080/2162402X.2016.1248015, PubMed 28123884

Fjeldbo CS, Julin CH, Lando M, Forsberg MF, Aarnes EK, Alsner J, Kristensen GB, Malinen E, Lyng H (2016)
Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer
Clin Cancer Res, 22 (16), 4067-76
DOI 10.1158/1078-0432.CCR-15-2322, PubMed 27012812

Fjeldbo CS, Aarnes EK, Malinen E, Kristensen GB, Lyng H (2016)
Identification and Validation of Reference Genes for RT-qPCR Studies of Hypoxia in Squamous Cervical Cancer Patients
PLoS One, 11 (5), e0156259
DOI 10.1371/journal.pone.0156259, PubMed 27244197

Glimelius B, Myklebust TÅ, Lundqvist K, Wibe A, Guren MG (2016)
Two countries - Two treatment strategies for rectal cancer
Radiother Oncol, 121 (3), 357-363
DOI 10.1016/j.radonc.2016.11.010, PubMed 27887734

Halvorsen AR, Bjaanæs M, LeBlanc M, Holm AM, Bolstad N, Rubio L, Peñalver JC, Cervera J, Mojarrieta JC, López-Guerrero JA, Brustugun OT, Helland Å (2016)
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer
Oncotarget, 7 (24), 37250-37259
DOI 10.18632/oncotarget.9363, PubMed 27191990

Halvorsen AR, Helland Å, Gromov P, Wielenga VT, Talman MM, Brunner N, Sandhu V, Børresen-Dale AL, Gromova I, Haakensen VD (2016)
Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer
Mol Oncol, 11 (2), 220-234
DOI 10.1002/1878-0261.12025, PubMed 28145100

Halvorsen AR, Silwal-Pandit L, Meza-Zepeda LA, Vodak D, Vu P, Sagerup C, Hovig E, Myklebost O, Børresen-Dale AL, Brustugun OT, Helland Å (2016)
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG (2016)
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779

Helland A (2016)
MicroRNA-profiles in lung adenocarcinomas
Expert Rev. Precis. Med. Drug Dev., 1 (5), 469-474
DOI 10.1080/23808993.2016.1240011

Haakensen VD, Nygaard V, Greger L, Aure MR, Fromm B, Bukholm IR, Lüders T, Chin SF, Git A, Caldas C, Kristensen VN, Brazma A, Børresen-Dale AL, Hovig E, Helland Å (2016)
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer, 139 (5), 1117-28
DOI 10.1002/ijc.30142, PubMed 27082076

Indelicato DJ, Merchant T, Laperriere N, Lassen Y, Vennarini S, Wolden S, Hartsell W, Pankuch M, Brandal P, Law CK, Taylor R, Laskar S, Okcu MF, Bouffet E, Mandeville H, Björk-Eriksson T, Nilsson K, Nyström H, Constine LS, Story M, Timmermann B, Roberts K, Kortmann RD (2016)
Consensus Report From the Stockholm Pediatric Proton Therapy Conference
Int J Radiat Oncol Biol Phys, 96 (2), 387-392
DOI 10.1016/j.ijrobp.2016.06.2446, PubMed 27598806

Joly-Battaglini A, Hammarström C, Stankovic B, Aamodt H, Stjärne J, Brustugun OT, Helland Å, Øynebråten I, Corthay A (2016)
Rituximab efficiently depletes B cells in lung tumors and normal lung tissue
F1000Res, 5, 38
DOI 10.12688/f1000research.7599.1, PubMed 27081474

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H (2016)
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
DOI 10.1038/bjc.2016.278, PubMed 27599042

Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, Jain RK, Batchelor TT, Gerstner ER (2016)
Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma
J Neurooncol, 131 (3), 603-610
DOI 10.1007/s11060-016-2332-5, PubMed 27853960

Knudtsen IS, Svestad JG, Skaug Sande EP, Rekstad BL, Rødal J, van Elmpt W, Öllers M, Hole EO, Malinen E (2016)
Validation of dose painting of lung tumours using alanine/EPR dosimetry
Phys Med Biol, 61 (6), 2243-54
DOI 10.1088/0031-9155/61/6/2243, PubMed 26913997

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2016)
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169

Lilleby W, Stensvold A, Dahl AA (2016)
Fatigue and other adverse effects in men treated by pelvic radiation and long-term androgen deprivation for locally advanced prostate cancer
Acta Oncol, 55 (7), 807-13
DOI 10.3109/0284186X.2015.1127417, PubMed 26959297

McGowan M, Hoven AS, Lund-Iversen M, Solberg S, Helland Å, Hirsch FR, Brustugun OT (2016)
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma
Lung Cancer, 103, 52-57
DOI 10.1016/j.lungcan.2016.11.018, PubMed 28024696

Olsen TK, Panagopoulos I, Gorunova L, Micci F, Andersen K, Kilen Andersen H, Meling TR, Due-Tønnessen B, Scheie D, Heim S, Brandal P (2016)
Novel fusion genes and chimeric transcripts in ependymal tumors
Genes Chromosomes Cancer, 55 (12), 944-953
DOI 10.1002/gcc.22392, PubMed 27401149

Paur I, Lilleby W, Bøhn SK, Hulander E, Klein W, Vlatkovic L, Axcrona K, Bolstad N, Bjøro T, Laake P, Taskén KA, Svindland A, Eri LM, Brennhovd B, Carlsen MH, Fosså SD, Smeland SS, Karlsen AS, Blomhoff R (2016)
Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA
Clin Nutr, 36 (3), 672-679
DOI 10.1016/j.clnu.2016.06.014, PubMed 27406859

Rud AK, Boye K, Fodstad Ø, Juell S, Jørgensen LH, Solberg S, Helland Å, Brustugun OT, Mælandsmo GM (2016)
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
Diagn Pathol, 11 (1), 50
DOI 10.1186/s13000-016-0504-4, PubMed 27316334

Røhrl K, Guren MG, Miaskowski C, Cooper BA, Diep LM, Rustøen T (2016)
No Differences in Symptom Burden Between Colorectal Cancer Patients Receiving Curative Versus Palliative Chemotherapy
J Pain Symptom Manage, 52 (4), 539-547
DOI 10.1016/j.jpainsymman.2016.04.008, PubMed 27470003

Torheim T, Groendahl AR, Andersen EK, Lyng H, Malinen E, Kvaal K, Futsaether CM (2016)
Cluster analysis of dynamic contrast enhanced MRI reveals tumor subregions related to locoregional relapse for cervical cancer patients
Acta Oncol, 55 (11), 1294-1298
DOI 10.1080/0284186X.2016.1189091, PubMed 27564398

Vandraas K, Tjønnfjord GE, Johannesen TB, Brandal P (2016)
Persistent bone marrow depression following short-term treatment with temozolomide
BMJ Case Rep, 2016
DOI 10.1136/bcr-2016-215797, PubMed 27130558

Varghese M, Nymoen HG, Saxhaug C, Krossnes B, Abdol Mohieb Hosainey S, Meling TR, Brandal P (2016)
Symptomatic spinal metastasis from intracranial glioblastoma multiforme - Two illustrative cases and a review of the literature
Acta Oncol, 55 (9-10), 1236-1238
DOI 10.3109/0284186X.2016.1161824, PubMed 27174685

Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R et al. (2016)
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Nat Genet, 49 (1), 65-74
DOI 10.1038/ng.3722, PubMed 27869826

Wilting SM, Miok V, Jaspers A, Boon D, Sørgård H, Lando M, Snoek BC, van Wieringen WN, Meijer CJ, Lyng H, Snijders PJ, Steenbergen RD (2016)
Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence
Oncotarget, 7 (28), 43805-43819
DOI 10.18632/oncotarget.9698, PubMed 27270309

Publications 2015

Arnesen MR, Knudtsen IS, Rekstad BL, Eilertsen K, Dale E, Bruheim K, Helland Å, Løndalen AM, Hellebust TP, Malinen E (2015)
Dose painting by numbers in a standard treatment planning system using inverted dose prescription maps
Acta Oncol, 54 (9), 1607-13
DOI 10.3109/0284186X.2015.1061690, PubMed 26213311

Berg J, Fjellbirkeland L, Suhrke P, Jebsen P, Lund-Iversen M, Kleinberg L, Helgeland L, Brustugun OT, Helland Å (2015)
EGFR mutation testing of lung cancer patients - Experiences from Vestfold Hospital Trust
Acta Oncol, 55 (2), 149-55
DOI 10.3109/0284186X.2015.1062537, PubMed 26313507

Bjaanæs MM, Fleischer T, Halvorsen AR, Daunay A, Busato F, Solberg S, Jørgensen L, Kure E, Edvardsen H, Børresen-Dale AL, Brustugun OT, Tost J, Kristensen V, Helland Å (2015)
Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
Mol Oncol, 10 (2), 330-43
DOI 10.1016/j.molonc.2015.10.021, PubMed 26601720

Cameron MG, Kersten C, Vistad I, van Helvoirt R, Weyde K, Undseth C, Mjaaland I, Skovlund E, Fosså SD, Guren MG (2015)
Palliative pelvic radiotherapy for symptomatic incurable prostate cancer – A prospective multicenter study
Radiother Oncol, 115 (3), 314-20
DOI 10.1016/j.radonc.2015.05.021, PubMed 26091575

Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S, Humphreys K, Thompson D, Ghoussaini M, Bolla MK, Dennis J, Wang Q, Canisius S, Scott CG, Apicella C, Hopper JL, Southey MC, Stone J, Broeks A, Schmidt MK, Scott RJ, Lophatananon A, Muir K, Beckmann MW, Ekici AB et al. (2015)
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
Am J Hum Genet, 97 (1), 22-34
DOI 10.1016/j.ajhg.2015.05.002, PubMed 26073781

Donnem T, Hald SM, Paulsen EE, Richardsen E, Al-Saad S, Kilvaer TK, Brustugun OT, Helland A, Lund-Iversen M, Poehl M, Olsen KE, Ditzel HJ, Hansen O, Al-Shibli K, Kiselev Y, Sandanger TM, Andersen S, Pezzella F, Bremnes RM, Busund LT (2015)
Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer
Clin Cancer Res, 21 (11), 2635-43
DOI 10.1158/1078-0432.CCR-14-1905, PubMed 25680376

Due-Tønnessen BJ, Egge A, Lundar T, Krossnes B, Stensvold E, Due-Tønnessen P, Brandal P (2015)
Posterior fossa ependymoblastoma diagnosed in the second month of life: uneventful 12 years survival after gross total resection followed by chemotherapy
Springerplus, 4, 389
DOI 10.1186/s40064-015-1178-1, PubMed 26251773

Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z et al. (2015)
Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Genome Biol, 16, 7
DOI 10.1186/s13059-014-0558-0, PubMed 25650807

Gerstner ER, Emblem KE, Sorensen GA (2015)
Vascular Magnetic Resonance Imaging in Brain Tumors During Antiangiogenic Therapy--Are We There Yet?
Cancer J, 21 (4), 337-42
DOI 10.1097/PPO.0000000000000128, PubMed 26222087

Guren MG, Kørner H, Pfeffer F, Myklebust TÅ, Eriksen MT, Edna TH, Larsen SG, Knudsen KO, Nesbakken A, Wasmuth HH, Vonen B, Hofsli E, Færden AE, Brændengen M, Dahl O, Steigen SE, Johansen MJ, Lindsetmo RO, Drolsum A, Tollåli G, Dørum LM, Møller B, Wibe A (2015)
Nationwide improvement of rectal cancer treatment outcomes in Norway, 1993-2010
Acta Oncol, 54 (10), 1714-22
DOI 10.3109/0284186X.2015.1034876, PubMed 25924970

Heck A, Emblem KE, Casar-Borota O, Bollerslev J, Ringstad G (2015)
Quantitative analyses of T2-weighted MRI as a potential marker for response to somatostatin analogs in newly diagnosed acromegaly
Endocrine, 52 (2), 333-43
DOI 10.1007/s12020-015-0766-8, PubMed 26475495

Heck A, Emblem KE, Casar-Borota O, Ringstad G, Bollerslev J (2015)
MRI T2 characteristics in somatotroph adenomas following somatostatin analog treatment in acromegaly
Endocrine, 53 (1), 327-30
DOI 10.1007/s12020-015-0816-2, PubMed 26615593

Helland A (2015)
Gene jockeys Life science and the rise of biotech enterprise.
Tidsskr. Nor. Laegeforen., 135 (4), 356
DOI 10.4045/tidsskr.14.1367

Helland A (2015)
Cancer stem cells
Tidsskr. Nor. Laegeforen., 135 (8), 783
DOI 10.4045/tidsskr.15.0031

Helland A (2015)
Viruses and human cancer
Tidsskr. Nor. Laegeforen., 135 (9), 874
DOI 10.4045/tidsskr.15.0167

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
DOI 10.1093/nar/gkv744, PubMed 26250117

Jafari-Khouzani K, Emblem KE, Kalpathy-Cramer J, Bjørnerud A, Vangel MG, Gerstner ER, Schmainda KM, Paynabar K, Wu O, Wen PY, Batchelor T, Rosen B, Stufflebeam SM (2015)
Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients
Transl Oncol, 8 (3), 137-46
DOI 10.1016/j.tranon.2015.03.002, PubMed 26055170

Juuhl-Langseth M, Hartberg CB, Holmén A, Thormodsen R, Groote IR, Rimol LM, Emblem KE, Agartz I, Rund BR (2015)
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders
PLoS One, 10 (7), e0130435
DOI 10.1371/journal.pone.0130435, PubMed 26230626

Labori KJ, Schulz A, Drolsum A, Guren MG, Kløw NE, Bjørnbeth BA (2015)
Radiofrequency ablation of unresectable colorectal liver metastases: trends in management and outcome during a decade at a single center
Acta Radiol Open, 4 (7), 2058460115580877
DOI 10.1177/2058460115580877, PubMed 26346740

Lando M, Fjeldbo CS, Wilting SM, C Snoek B, Aarnes EK, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H (2015)
Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer
Epigenetics, 10 (10), 970-80
DOI 10.1080/15592294.2015.1085140, PubMed 26291246

Leon O, Guren MG, Radu C, Gunnlaugsson A, Johnsson A (2015)
Phase I study of cetuximab in combination with 5-fluorouracil, mitomycin C and radiotherapy in patients with locally advanced anal cancer
Eur J Cancer, 51 (18), 2740-6
DOI 10.1016/j.ejca.2015.08.029, PubMed 26597443

Lilleby W, Narrang A, Tafjord G, Vlatkovic L, Russnes KM, Stensvold A, Hole KH, Tran P, Eilertsen K (2015)
Favorable outcomes in locally advanced and node positive prostate cancer patients treated with combined pelvic IMRT and androgen deprivation therapy
Radiat Oncol, 10, 232
DOI 10.1186/s13014-015-0540-3, PubMed 26577452

Lilleby W, Raabe NK, Normann M (2015)
[Re: The problematical prostate cancer]
Tidsskr Nor Laegeforen, 135 (11), 1009
DOI 10.4045/tidsskr.15.0593, PubMed 26080763

Lilleby W, Vlatkovic L, Meza-Zepeda LA, Revheim ME, Hovig E (2015)
Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report
J Med Case Rep, 9, 281
DOI 10.1186/s13256-015-0749-7, PubMed 26654961

Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK (2015)
Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma
J Clin Oncol, 33 (10), 1197-213
DOI 10.1200/JCO.2014.55.9575, PubMed 25713439

Lund-Iversen M, Grøholt KK, Helland Å, Borgen E, Brustugun OT (2015)
NUT expression in primary lung tumours
Diagn Pathol, 10, 156
DOI 10.1186/s13000-015-0395-9, PubMed 26341600

Lundar T, Due-Tønnessen BJ, Egge A, Krossnes B, Stensvold E, Due-Tønnessen P, Brandal P (2015)
Neurosurgical treatment of brain tumors in the first 6 months of life: long-term follow-up of a single consecutive institutional series of 30 patients
Childs Nerv Syst, 31 (12), 2283-90
DOI 10.1007/s00381-015-2792-5, PubMed 26174616

Lundar T, Due-Tønnessen BJ, Krossnes B, Due-Tønnessen P, Brandal P (2015)
Posterior fossa ependymoma in childhood: 60 years event-free survival after partial resection—a case report
Childs Nerv Syst, 31 (9), 1573-6
DOI 10.1007/s00381-015-2766-7, PubMed 26047947

Malinen E, Søvik Å (2015)
Dose or 'LET' painting--What is optimal in particle therapy of hypoxic tumors?
Acta Oncol, 54 (9), 1614-22
DOI 10.3109/0284186X.2015.1062540, PubMed 26198655

Nilsen TS, Raastad T, Skovlund E, Courneya KS, Langberg CW, Lilleby W, Fosså SD, Thorsen L (2015)
Effects of strength training on body composition, physical functioning, and quality of life in prostate cancer patients during androgen deprivation therapy
Acta Oncol, 54 (10), 1805-13
DOI 10.3109/0284186X.2015.1037008, PubMed 25927504

Olsen TK, Panagopoulos I, Meling TR, Micci F, Gorunova L, Thorsen J, Due-Tønnessen B, Scheie D, Lund-Iversen M, Krossnes B, Saxhaug C, Heim S, Brandal P (2015)
Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity?
Neuro Oncol, 17 (10), 1365-73
DOI 10.1093/neuonc/nov039, PubMed 25795305

Pitman KE, Rusten E, Kristian A, Malinen E (2015)
Variability of dynamic 18F-FDG-PET data in breast cancer xenografts
Acta Oncol, 54 (9), 1399-407
DOI 10.3109/0284186X.2015.1062140, PubMed 26217987

Potapenko IO, Lüders T, Russnes HG, Helland Å, Sørlie T, Kristensen VN, Nord S, Lingjærde OC, Børresen-Dale AL, Haakensen VD (2015)
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival
Mol Oncol, 9 (4), 861-76
DOI 10.1016/j.molonc.2014.12.013, PubMed 25655580

Ringstad G, Emblem KE, Eide PK (2015)
Phase-contrast magnetic resonance imaging reveals net retrograde aqueductal flow in idiopathic normal pressure hydrocephalus
J Neurosurg, 124 (6), 1850-7
DOI 10.3171/2015.6.JNS15496, PubMed 26636385

Ringstad G, Emblem KE, Geier O, Alperin N, Eide PK (2015)
Aqueductal Stroke Volume: Comparisons with Intracranial Pressure Scores in Idiopathic Normal Pressure Hydrocephalus
AJNR Am J Neuroradiol, 36 (9), 1623-30
DOI 10.3174/ajnr.A4340, PubMed 25977480

Ringstad G, Emblem KE, Geier O, Alperin N, Eide PK (2015)
Reply: To PMID 25977480
AJNR Am J Neuroradiol, 36 (9), 1633-4
DOI 10.3174/ajnr.A4488, PubMed 26251437

Raabe NK, Normann M, Lilleby W (2015)
Low-dose-rate brachytherapy for low-grade prostate cancer
Tidsskr Nor Laegeforen, 135 (6), 548-52
DOI 10.4045/tidsskr.13.1404, PubMed 25806763

Solberg A, Angelsen A, Berge V, Lilleby W, Iversen J, Klepp O, Brennhovd B, Johannessen D, Nygård Y, Larsen K, Stensvold A (2015)
[Re: Different guidelines for treatment of prostate cancer]
Tidsskr Nor Laegeforen, 135 (12-13), 1105
DOI 10.4045/tidsskr.15.0652, PubMed 26130530

Syljuåsen RG, Hasvold G, Hauge S, Helland Å (2015)
Targeting lung cancer through inhibition of checkpoint kinases
Front Genet, 6, 70
DOI 10.3389/fgene.2015.00070, PubMed 25774168

Walters S, Benitez-Majano S, Muller P, Coleman MP, Allemani C, Butler J, Peake M, Guren MG, Glimelius B, Bergström S, Påhlman L, Rachet B (2015)
Is England closing the international gap in cancer survival?
Br J Cancer, 113 (5), 848-60
DOI 10.1038/bjc.2015.265, PubMed 26241817

Witek B, El Wakil A, Nord C, Ahlgren U, Eriksson M, Vernersson-Lindahl E, Helland Å, Alexeyev OA, Hallberg B, Palmer RH (2015)
Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism
PLoS One, 10 (5), e0123542
DOI 10.1371/journal.pone.0123542, PubMed 25955180