Randi Gussgard Syljuåsen
- Scientist, Group Leader Ph.D
- +47 22 78 14 68
Mobile phone: +47 474 48 822
Fax: +47 22 78 14 95
1996: Ph.D., University of California, Los Angeles (UCLA).
1991: Sivilingeniør (M.Sc), The Norwegian Institute of Technology (NTNU).
2012: - Group Leader, Dept Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
2007-2012: Project group leader, Dept Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
2007 (6 months): Guest researcher, BRIC Biocenter, Copenhagen University, Denmark.
1999-2006: Postdoc, Dept Cell Cycle and Cancer, The Danish Cancer Society, Copenhagen, Denmark.
1997-1998: Postdoc, Laboratory of Radiobiology, Harvard School of Public Health, Boston, USA.
1996-1997: Postdoc, Dept Radiation Oncology, UCLA, USA.
S. Hauge, C. Naucke, G. Hasvold, M. Joel, G.E. Rødland, P. Juzenas, T. Stokke, R.G. Syljuåsen. Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading. Oncotargets, In press, 2016.
T.W. Håland, E.Boye, T.Stokke, B.Grallert, R.G. Syljuåsen. Simultaneous measurement of passage through the restriction point and MCM loading in single cells. Nucleic Acids Res, 43 (22), e150, 2015.
C. Lund-Andersen, S. Patzke, V. Nähse-Kumpf, R.G. Syljuåsen. Plk1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule. Radiation Therapy and Oncology, 110, p.355-361, 2014.
G. Hasvold, V. Nähse-Kumpf, K. Tkacz-Stachowska, E. Rofstad, R.G. Syljuåsen. The efficacy of CHK1-inhibitors is not altered by hypoxia, but is enhanced after reoxygenation. Molecular Cancer Therapeutics, 12, 705-716, 2013.
H.Beck,V. Nähse-Kumpf, M.S Yoo Larsen, S. Patzke, C. Holmberg, O. Nielsen, R.G. Syljuåsen*, C.S. Sørensen*. CDK suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol. Cell. Biol., 32, 4226-4236, 2012. *shared corresponding authorship
C.S. Sørensen, R.G. Syljuåsen. Safeguarding genome integrity: The checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Research, 40, 477-486, 2012.
T. Menzel, V. Nähse-Kumpf, A. Nedergaard Kousholt, D. Kjærsgaard Klein, C. Lund-Andersen, M. Lees, J. Vilstrup Johansen, R.G. Syljuåsen*, C. S. Sørensen*. A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance. EMBO Reports, 12, 705-712,2011. *shared corresponding authorship
H.B. Landsverk, F. Mora-Bermudez, O.J.B. Landsverk, G. Hasvold, S. Naderi, O. Bakke, J. Ellenberg, P. Collas, R.G. Syljuåsen*, T. Küntziger*. The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Reports, 11,868-75, 2010. *shared corresponding authorship
R.G. Syljuåsen. Checkpoint adaptation in human cells. Oncogene, 26, p.5833-5839, 2007.
R.G. Syljuåsen, S. Jensen, J. Bartek and J. Lukas. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on Chk1 and Plk1 kinases. Cancer Research, 66, p. 10253-10257, 2006.
R.G. Syljuåsen, C.S. Sørensen, L.T. Hansen, K.Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, and J. Bartek. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and Cellular Biology, 25, p.3553-3562, 2005.
C.S. Sørensen*, R.G. Syljuåsen*, J. Falck, T. Schroeder, L. Rönnstrand, K.K. Khanna, B.B. Zhou, J. Bartek, and J. Lukas. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3, p. 247-258, 2003.
N. Mailand, J. Falck, C. Lukas, R. G. Syljuåsen, M. Welcker, J. Bartek and J. Lukas. Rapid destruction of human cdc25A in response to DNA damage. Science, 288, p. 1425-1429, 2000.
R.G. Syljuåsen, B. Krolewski and J. B. Little. Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53-status. Cancer Research, 59, p.1008-1014, 1999.
R.G. Syljuåsen, A. Belldegrun, C-L. Tso, H.R. Withers and W.H. McBride: Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection. Radiation Research, 148, p.443-448, 1997.
A novel role for ATR/Rad3 in G1 phase
Sci Rep, 8 (1), 6880
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
Nucleic Acids Res (in press)
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
Targeting lung cancer through inhibition of checkpoint kinases
Front Genet, 6, 70
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy
Int J Cancer, 135 (9), 2085-95
PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule
Radiother Oncol, 110 (2), 355-61
The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation
Mol Cancer Ther, 12 (5), 705-16
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
Mol Cell Biol, 32 (20), 4226-36
Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI
Cancer Res, 72 (20), 5285-95
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
J Cell Biol, 192 (1), 43-54
Protein phosphatase 1 regulators in DNA damage signaling
Cell Cycle, 10 (9), 1356-62
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
EMBO Rep, 12 (7), 705-12
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
Nucleic Acids Res, 40 (2), 477-86
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Radiother Oncol, 101 (1), 24-7
High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells
Cell Cycle, 9 (12), 2257-8
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
J Cell Biol, 188 (5), 629-38
The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response
EMBO Rep, 11 (11), 868-75
p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors
Cell Prolif, 43 (4), 365-71
Checkpoint adaptation in human cells
Oncogene, 26 (40), 5833-9
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
Cancer Res, 66 (21), 10253-7
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
Mol Cell Biol, 25 (9), 3553-62
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Nat Cell Biol, 7 (2), 195-201
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Nat Cell Biol, 6 (9), 884-91
Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation
Cancer Res, 64 (24), 9035-40
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Cell Cycle, 3 (7), 941-5
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
J Biol Chem, 278 (17), 14806-11
Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
Oncogene, 22 (50), 8063-71
The role of the ubiquitin/proteasome system in cellular responses to radiation
Oncogene, 22 (37), 5755-73
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
Cancer Cell, 3 (3), 247-58
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
Nature, 410 (6830), 842-7
Molecular events in radiation transformation
Radiat Res, 155 (1 Pt 2), 215-221
Rapid destruction of human Cdc25A in response to DNA damage
Science, 288 (5470), 1425-9
c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency
Proc Natl Acad Sci U S A, 97 (10), 5486-91
Radiation-induced apoptosis and cell cycle progression in Jurkat T cells
Radiat Res, 152 (3), 328-31
Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status
Cancer Res, 59 (5), 1008-14
Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo
Cancer Res, 57 (18), 3899-903
Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection
Radiat Res, 148 (5), 443-8
The effects of cytokine gene transfer into tumors on host cell infiltration and regression
Anticancer Res, 16 (3A), 1139-43
Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells
Radiat Res, 146 (3), 276-82
Modification of tumor microenvironment by cytokine gene transfer
Acta Oncol, 34 (3), 447-51
CALCULATION OF THE TRAPPING FORCE IN A STRONGLY FOCUSED LASER-BEAM
J. Opt. Soc. Am. B-Opt. Phys., 9 (10), 1922-1930