Randi Gussgard Syljuåsen

  • Scientist, Group Leader Ph.D
  • +47 22 78 14 68

Mobile phone: +47 474 48 822
Fax: +47 22 78 14 95

Education:
1996: Ph.D., University of California, Los Angeles (UCLA). 
1991: Sivilingeniør (M.Sc), The Norwegian Institute of Technology (NTNU). 

Positions:
2012: - Group Leader, Dept Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
2007-2012: Project group leader, Dept Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
2007 (6 months): Guest researcher, BRIC Biocenter, Copenhagen University, Denmark.
1999-2006: Postdoc, Dept Cell Cycle and Cancer, The Danish Cancer Society, Copenhagen, Denmark.
1997-1998: Postdoc, Laboratory of Radiobiology, Harvard School of Public Health, Boston, USA.
1996-1997: Postdoc, Dept Radiation Oncology, UCLA, USA.

Selected publications:

S. Hauge, C. Naucke, G. Hasvold, M. Joel, G.E. Rødland, P. Juzenas, T. Stokke, R.G. Syljuåsen. Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading”. Oncotargets, In press, 2016.

T.W. Håland, E.Boye, T.Stokke, B.Grallert, R.G. Syljuåsen. Simultaneous measurement of passage through the restriction point and MCM loading in single cells. Nucleic Acids Res, 43 (22), e150, 2015.

C. Lund-Andersen, S. Patzke, V. Nähse-Kumpf, R.G. Syljuåsen. Plk1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule. Radiation Therapy and Oncology, 110, p.355-361, 2014.

G. Hasvold, V. Nähse-Kumpf, K. Tkacz-Stachowska, E. Rofstad, R.G. Syljuåsen. The efficacy of CHK1-inhibitors is not altered by hypoxia, but is enhanced after reoxygenation. Molecular Cancer Therapeutics, 12, 705-716, 2013.

H.Beck,V. Nähse-Kumpf, M.S Yoo Larsen, S. Patzke, C. Holmberg, O. Nielsen, R.G. Syljuåsen*, C.S. Sørensen*. CDK suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol. Cell. Biol., 32, 4226-4236, 2012. *shared corresponding authorship

C.S. Sørensen, R.G. Syljuåsen. Safeguarding genome integrity: The checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Research, 40, 477-486, 2012.

T. Menzel, V. Nähse-Kumpf, A. Nedergaard Kousholt, D. Kjærsgaard Klein, C. Lund-Andersen, M. Lees, J. Vilstrup Johansen, R.G. Syljuåsen*, C. S. Sørensen*. A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance. EMBO Reports, 12, 705-712,2011. *shared corresponding authorship

H.B. Landsverk, F. Mora-Bermudez, O.J.B. Landsverk, G. Hasvold, S. Naderi, O. Bakke, J. Ellenberg, P. Collas, R.G. Syljuåsen*, T. Küntziger*. The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Reports, 11,868-75, 2010. *shared corresponding authorship

R.G. Syljuåsen. Checkpoint adaptation in human cells. Oncogene, 26, p.5833-5839, 2007.

R.G. Syljuåsen, S. Jensen, J. Bartek and J. Lukas. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on Chk1 and Plk1 kinases. Cancer Research, 66, p. 10253-10257, 2006.

R.G. Syljuåsen, C.S. Sørensen, L.T. Hansen, K.Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, and J. Bartek. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and Cellular Biology, 25, p.3553-3562, 2005.

C.S. Sørensen*, R.G. Syljuåsen*, J. Falck, T. Schroeder, L. Rönnstrand, K.K. Khanna, B.B. Zhou, J. Bartek, and J. Lukas. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3, p. 247-258, 2003.
*shared 1st-authorship

N. Mailand, J. Falck, C. Lukas, R. G. Syljuåsen, M. Welcker, J. Bartek and J. Lukas. Rapid destruction of human cdc25A in response to DNA damage. Science, 288, p. 1425-1429, 2000.

R.G. Syljuåsen, B. Krolewski and J. B. Little. Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53-status. Cancer Research, 59, p.1008-1014, 1999.

R.G. Syljuåsen, A. Belldegrun, C-L. Tso, H.R. Withers and W.H. McBride: Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection. Radiation Research, 148, p.443-448, 1997.

 

Author network for Randi Gussgard Syljuåsen by COREMINE medical


Publications 2018

Bøe CA, Håland TW, Boye E, Syljuåsen RG, Grallert B (2018)
A novel role for ATR/Rad3 in G1 phase
Sci Rep, 8 (1), 6880
DOI 10.1038/s41598-018-25238-6, PubMed 29720710

Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG (2018)
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
Nucleic Acids Res (in press)
DOI 10.1093/nar/gky1233, PubMed 30541148

Publications 2017

Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T, Syljuåsen RG (2017)
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
DOI 10.18632/oncotarget.14089, PubMed 28030798

Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK (2017)
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708, PubMed 28973009

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2017)
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
DOI 10.18632/oncotarget.14800, PubMed 28179591

Publications 2016

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG (2016)
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2016)
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169

Publications 2015

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
DOI 10.1093/nar/gkv744, PubMed 26250117

Syljuåsen RG, Hasvold G, Hauge S, Helland Å (2015)
Targeting lung cancer through inhibition of checkpoint kinases
Front Genet, 6, 70
DOI 10.3389/fgene.2015.00070, PubMed 25774168

Publications 2014

Halvorsen AR, Helland A, Fleischer T, Haug KM, Grenaker Alnaes GI, Nebdal D, Syljuåsen RG, Touleimat N, Busato F, Tost J, Saetersdal AB, Børresen-Dale AL, Kristensen V, Edvardsen H (2014)
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy
Int J Cancer, 135 (9), 2085-95
DOI 10.1002/ijc.28862, PubMed 24658971

Lund-Andersen C, Patzke S, Nähse-Kumpf V, Syljuåsen RG (2014)
PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule
Radiother Oncol, 110 (2), 355-61
DOI 10.1016/j.radonc.2013.12.014, PubMed 24502970

Publications 2013

Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG (2013)
The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation
Mol Cancer Ther, 12 (5), 705-16
DOI 10.1158/1535-7163.MCT-12-0879, PubMed 23635654

Publications 2012

Beck H, Nähse-Kumpf V, Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS (2012)
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
Mol Cell Biol, 32 (20), 4226-36
DOI 10.1128/MCB.00412-12, PubMed 22907750

Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H (2012)
Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI
Cancer Res, 72 (20), 5285-95
DOI 10.1158/0008-5472.CAN-12-1085, PubMed 22890239

Publications 2011

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS (2011)
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
J Cell Biol, 192 (1), 43-54
DOI 10.1083/jcb.201009076, PubMed 21220508

Küntziger T, Landsverk HB, Collas P, Syljuåsen RG (2011)
Protein phosphatase 1 regulators in DNA damage signaling
Cell Cycle, 10 (9), 1356-62
DOI 10.4161/cc.10.9.15442, PubMed 21451260

Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS (2011)
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
EMBO Rep, 12 (7), 705-12
DOI 10.1038/embor.2011.99, PubMed 21637299

Sørensen CS, Syljuåsen RG (2011)
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
Nucleic Acids Res, 40 (2), 477-86
DOI 10.1093/nar/gkr697, PubMed 21937510

Tkacz-Stachowska K, Lund-Andersen C, Velissarou A, Myklebust JH, Stokke T, Syljuåsen RG (2011)
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Radiother Oncol, 101 (1), 24-7
DOI 10.1016/j.radonc.2011.05.060, PubMed 21722983

Publications 2010

Beck H, Menzel T, Syljuåsen RG, Sørensen CS (2010)
High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells
Cell Cycle, 9 (12), 2257-8
DOI 10.4161/cc.9.12.12017, PubMed 20699633

Beck H, Nähse V, Larsen MS, Groth P, Clancy T, Lees M, Jørgensen M, Helleday T, Syljuåsen RG, Sørensen CS (2010)
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
J Cell Biol, 188 (5), 629-38
DOI 10.1083/jcb.200905059, PubMed 20194642

Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T (2010)
The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response
EMBO Rep, 11 (11), 868-75
DOI 10.1038/embor.2010.134, PubMed 20890310

Petersen L, Hasvold G, Lukas J, Bartek J, Syljuåsen RG (2010)
p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors
Cell Prolif, 43 (4), 365-71
DOI 10.1111/j.1365-2184.2010.00685.x, PubMed 20590661

Publications 2007

Syljuåsen RG (2007)
Checkpoint adaptation in human cells
Oncogene, 26 (40), 5833-9
DOI 10.1038/sj.onc.1210402, PubMed 17384683

Publications 2006

Syljuåsen RG, Jensen S, Bartek J, Lukas J (2006)
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
Cancer Res, 66 (21), 10253-7
DOI 10.1158/0008-5472.CAN-06-2144, PubMed 17079442

Publications 2005

Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J (2005)
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
Mol Cell Biol, 25 (9), 3553-62
DOI 10.1128/MCB.25.9.3553-3562.2005, PubMed 15831461

Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T (2005)
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Nat Cell Biol, 7 (2), 195-201
DOI 10.1038/ncb1212, PubMed 15665856

Publications 2004

Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J (2004)
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Nat Cell Biol, 6 (9), 884-91
DOI 10.1038/ncb1165, PubMed 15311285

Syljuåsen RG, Sørensen CS, Nylandsted J, Lukas C, Lukas J, Bartek J (2004)
Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation
Cancer Res, 64 (24), 9035-40
DOI 10.1158/0008-5472.CAN-04-2434, PubMed 15604269

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J (2004)
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Cell Cycle, 3 (7), 941-5
PubMed 15190204

Publications 2003

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK (2003)
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
J Biol Chem, 278 (17), 14806-11
DOI 10.1074/jbc.M210862200, PubMed 12588868

Löffler H, Syljuåsen RG, Bartkova J, Worm J, Lukas J, Bartek J (2003)
Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
Oncogene, 22 (50), 8063-71
DOI 10.1038/sj.onc.1206976, PubMed 14603247

McBride WH, Iwamoto KS, Syljuasen R, Pervan M, Pajonk F (2003)
The role of the ubiquitin/proteasome system in cellular responses to radiation
Oncogene, 22 (37), 5755-73
DOI 10.1038/sj.onc.1206676, PubMed 12947384

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J (2003)
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
Cancer Cell, 3 (3), 247-58
PubMed 12676583

Publications 2001

Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J (2001)
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
Nature, 410 (6830), 842-7
DOI 10.1038/35071124, PubMed 11298456

Syljuåsen RG, Krolewski B, Little JB (2001)
Molecular events in radiation transformation
Radiat Res, 155 (1 Pt 2), 215-221
PubMed 11121237

Publications 2000

Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J (2000)
Rapid destruction of human Cdc25A in response to DNA damage
Science, 288 (5470), 1425-9
PubMed 10827953

Whang YE, Tran C, Henderson C, Syljuasen RG, Rozengurt N, McBride WH, Sawyers CL (2000)
c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency
Proc Natl Acad Sci U S A, 97 (10), 5486-91
PubMed 10805805

Publications 1999

Syljuâsen RG, McBride WH (1999)
Radiation-induced apoptosis and cell cycle progression in Jurkat T cells
Radiat Res, 152 (3), 328-31
PubMed 10453094

Syljuåsen RG, Krolewski B, Little JB (1999)
Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status
Cancer Res, 59 (5), 1008-14
PubMed 10070956

Publications 1997

Chiang CS, Syljuäsen RG, Hong JH, Wallis A, Dougherty GJ, McBride WH (1997)
Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo
Cancer Res, 57 (18), 3899-903
PubMed 9307268

Syljuåsen RG, Belldegrun A, Tso CL, Withers HR, McBride WH (1997)
Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection
Radiat Res, 148 (5), 443-8
PubMed 9355869

Publications 1996

McBride WH, Economou JS, Syljuåsen RG, Parrish C, Hackman D, Latham V, Chiang CS, Dougherty GJ (1996)
The effects of cytokine gene transfer into tumors on host cell infiltration and regression
Anticancer Res, 16 (3A), 1139-43
PubMed 8702225

Syljuåsen RG, Hong JH, McBride WH (1996)
Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells
Radiat Res, 146 (3), 276-82
PubMed 8752305

Publications 1995

McBride WH, Economou JS, Kuber N, Hong JH, Chiang CS, Syljuasen R, Dougherty ST, Dougherty GJ (1995)
Modification of tumor microenvironment by cytokine gene transfer
Acta Oncol, 34 (3), 447-51
PubMed 7779438

Publications 1992

GUSSGARD R, LINDMO T, BREVIK I (1992)
CALCULATION OF THE TRAPPING FORCE IN A STRONGLY FOCUSED LASER-BEAM
J. Opt. Soc. Am. B-Opt. Phys., 9 (10), 1922-1930

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