Publications 2024

Blakstad H, Mendoza Mireles EE, Kierulf-Vieira KS, Singireddy D, Mdala I, Heggebø LC, Magelssen H, Sprauten M, Johannesen TB, Leske H, Niehusmann P, Skogen K, Helseth E, Emblem KE, Vik-Mo EO, Brandal P (2024)
The impact of cancer patient pathway on timing of radiotherapy and survival: a cohort study in glioblastoma patients
J Neurooncol, 169 (1), 137-145
DOI 10.1007/s11060-024-04709-z, PubMed 38762830

Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist R, Krop I, Lawrence D et al. (2024)
Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance
Neuro Oncol, 26 (5), 965-974
DOI 10.1093/neuonc/noad236, PubMed 38070147

Luque L, Skogen K, MacIntosh BJ, Emblem KE, Larsson C, Bouget D, Helland RH, Reinertsen I, Solheim O, Schellhorn T, Vardal J, Mireles EEM, Vik-Mo EO, Bjørnerud A (2024)
Standardized evaluation of the extent of resection in glioblastoma with automated early post-operative segmentation
Front Radiol, 4, 1357341
DOI 10.3389/fradi.2024.1357341, PubMed 38840717

Publications 2023

Blakstad H, Mendoza Mireles EE, Heggebø LC, Magelssen H, Sprauten M, Johannesen TB, Vik-Mo EO, Leske H, Niehusmann P, Skogen K, Helseth E, Emblem KE, Brandal P (2023)
Incidence and outcome of pseudoprogression after radiation therapy in glioblastoma patients: A cohort study
Neurooncol Pract, 11 (1), 36-45
DOI 10.1093/nop/npad063, PubMed 38222046

Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, Dong X, Speranza MC, Neagu MR, Iorgulescu JB, Huang RY, Youssef G, Reardon DA, Sharpe AH, Freeman GJ, Suvà ML et al. (2023)
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models
Proc Natl Acad Sci U S A, 120 (6), e2219199120
DOI 10.1073/pnas.2219199120, PubMed 36724255

Hangel G, Schmitz-Abecassis B, Sollmann N, Pinto J, Arzanforoosh F, Barkhof F, Booth T, Calvo-Imirizaldu M, Cassia G, Chmelik M, Clement P, Ercan E, Fernández-Seara MA, Furtner J, Fuster-Garcia E, Grech-Sollars M, Guven NT, Hatay GH, Karami G, Keil VC, Kim M, Koekkoek JAF, Kukran S, Mancini L, Nechifor RE et al. (2023)
Advanced MR Techniques for Preoperative Glioma Characterization: Part 2
J Magn Reson Imaging, 57 (6), 1676-1695
DOI 10.1002/jmri.28663, PubMed 36912262

Hirschler L, Sollmann N, Schmitz-Abecassis B, Pinto J, Arzanforoosh F, Barkhof F, Booth T, Calvo-Imirizaldu M, Cassia G, Chmelik M, Clement P, Ercan E, Fernández-Seara MA, Furtner J, Fuster-Garcia E, Grech-Sollars M, Guven NT, Hatay GH, Karami G, Keil VC, Kim M, Koekkoek JAF, Kukran S, Mancini L, Nechifor RE et al. (2023)
Advanced MR Techniques for Preoperative Glioma Characterization: Part 1
J Magn Reson Imaging, 57 (6), 1655-1675
DOI 10.1002/jmri.28662, PubMed 36866773

Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist R, Krop I, Lawrence D et al. (2023)
Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy
bioRxiv
DOI 10.1101/2023.08.25.554868, PubMed 37693537

Lauer A, Speroni SL, Choi M, Da X, Duncan C, McCarthy S, Krishnan V, Lusk CA, Rohde D, Hansen MB, Kalpathy-Cramer J, Loes DJ, Caruso PA, Williams DA, Mouridsen K, Emblem KE, Eichler FS, Musolino PL (2023)
Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy
Nat Commun, 14 (1), 1900
DOI 10.1038/s41467-023-37262-w, PubMed 37019892

Lysvik EK, Mikalsen LTG, Rootwelt-Revheim ME, Emblem KE, Hjørnevik T (2023)
Optimization of Q.Clear reconstruction for dynamic ¹⁸F PET imaging
EJNMMI Phys, 10 (1), 65
DOI 10.1186/s40658-023-00584-1, PubMed 37861929

MacIntosh BJ, Liu Q, Schellhorn T, Beyer MK, Groote IR, Morberg PC, Poulin JM, Selseth MN, Bakke RC, Naqvi A, Hillal A, Ullberg T, Wassélius J, Rønning OM, Selnes P, Kristoffersen ES, Emblem KE, Skogen K, Sandset EC, Bjørnerud A (2023)
Radiological features of brain hemorrhage through automated segmentation from computed tomography in stroke and traumatic brain injury
Front Neurol, 14, 1244672
DOI 10.3389/fneur.2023.1244672, PubMed 37840934

Osadebey M, Liu Q, Fuster-Garcia E, Emblem KE (2023)
Interpreting deep learning models for glioma survival classification using visualization and textual explanations
BMC Med Inform Decis Mak, 23 (1), 225
DOI 10.1186/s12911-023-02320-2, PubMed 37853371

Ottesen JA, Yi D, Tong E, Iv M, Latysheva A, Saxhaug C, Jacobsen KD, Helland Å, Emblem KE, Rubin DL, Bjørnerud A, Zaharchuk G, Grøvik E (2023)
2.5D and 3D segmentation of brain metastases with deep learning on multinational MRI data
Front Neuroinform, 16, 1056068
DOI 10.3389/fninf.2022.1056068, PubMed 36743439

Svensson SF, Halldórsson S, Latysheva A, Fuster-Garcia E, Hjørnevik T, Fraser-Green J, Birkeland Bugge RA, Grinband J, Holm S, Sinkus R, Vik-Mo EO, Emblem KE (2023)
MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients
Neurooncol Adv, 5 (1), vdad021
DOI 10.1093/noajnl/vdad021, PubMed 37066109

Yi D, Grøvik E, Tong E, Iv M, Emblem KE, Nilsen LB, Saxhaug C, Latysheva A, Jacobsen KD, Helland Å, Zaharchuk G, Rubin D (2023)
Erratum: "MRI pulse sequence integration for deep-learning-based brain metastases segmentation"
Med Phys, 50 (8), 5294
DOI 10.1002/mp.16594, PubMed 37573581

Publications 2022

Bouget D, Pedersen A, Jakola AS, Kavouridis V, Emblem KE, Eijgelaar RS, Kommers I, Ardon H, Barkhof F, Bello L, Berger MS, Conti Nibali M, Furtner J, Hervey-Jumper S, Idema AJS, Kiesel B, Kloet A, Mandonnet E, Müller DMJ, Robe PA, Rossi M, Sciortino T, Van den Brink WA, Wagemakers M, Widhalm G et al. (2022)
Preoperative Brain Tumor Imaging: Models and Software for Segmentation and Standardized Reporting
Front Neurol, 13, 932219
DOI 10.3389/fneur.2022.932219, PubMed 35968292

Fuster-Garcia E, Thokle Hovden I, Fløgstad Svensson S, Larsson C, Vardal J, Bjørnerud A, Emblem KE (2022)
Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival
Cancers (Basel), 14 (7)
DOI 10.3390/cancers14071725, PubMed 35406497

Harkos C, Svensson SF, Emblem KE, Stylianopoulos T (2022)
Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics
Cancers (Basel), 14 (4)
DOI 10.3390/cancers14040884, PubMed 35205632

Publications 2021

Álvarez-Torres MDM, Fuster-García E, Reynés G, Juan-Albarracín J, Chelebian E, Oleaga L, Pineda J, Auger C, Rovira A, Emblem KE, Filice S, Mollà-Olmos E, García-Gómez JM (2021)
Differential effect of vascularity between long- and short-term survivors with IDH1/2 wild-type glioblastoma
NMR Biomed, 34 (4), e4462
DOI 10.1002/nbm.4462, PubMed 33470039

Bannier E, Barker G, Borghesani V, Broeckx N, Clement P, Emblem KE, Ghosh S, Glerean E, Gorgolewski KJ, Havu M, Halchenko YO, Herholz P, Hespel A, Heunis S, Hu Y, Hu CP, Huijser D, de la Iglesia Vayá M, Jancalek R, Katsaros VK, Kieseler ML, Maumet C, Moreau CA, Mutsaerts HJ, Oostenveld R et al. (2021)
The Open Brain Consent: Informing research participants and obtaining consent to share brain imaging data
Hum Brain Mapp, 42 (7), 1945-1951
DOI 10.1002/hbm.25351, PubMed 33522661

Due-Tønnessen P, Pinho MC, Emblem KE, Hald JK, Kanoto M, Abildgaard A, Sederevicius D, Groote IR, Rapalino O, Bjørnerud A (2021)
Author Correction: The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma
Sci Rep, 11 (1), 20287
DOI 10.1038/s41598-021-99776-x, PubMed 34620996

Grøvik E, Yi D, Iv M, Tong E, Nilsen LB, Latysheva A, Saxhaug C, Jacobsen KD, Helland Å, Emblem KE, Rubin DL, Zaharchuk G (2021)
Handling missing MRI sequences in deep learning segmentation of brain metastases: a multicenter study
NPJ Digit Med, 4 (1), 33
DOI 10.1038/s41746-021-00398-4, PubMed 33619361

Kim M, Park JE, Emblem K, Bjørnerud A, Kim HS (2021)
Vessel Type Determined by Vessel Architectural Imaging Improves Differentiation between Early Tumor Progression and Pseudoprogression in Glioblastoma
AJNR Am J Neuroradiol, 42 (4), 663-670
DOI 10.3174/ajnr.A6984, PubMed 33541891

Petr J, Hogeboom L, Nikulin P, Wiegers E, Schroyen G, Kallehauge J, Chmelík M, Clement P, Nechifor RE, Fodor LA, De Witt Hamer PC, Barkhof F, Pernet C, Lequin M, Deprez S, Jančálek R, Mutsaerts HJMM, Pizzini FB, Emblem KE, Keil VC (2021)
A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue
MAGMA, 35 (1), 163-186
DOI 10.1007/s10334-021-00985-2, PubMed 34919195

Svensson SF, De Arcos J, Darwish OI, Fraser-Green J, Storås TH, Holm S, Vik-Mo EO, Sinkus R, Emblem KE (2021)
Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods
J Magn Reson Imaging, 53 (5), 1510-1521
DOI 10.1002/jmri.27475, PubMed 33403750

Yi D, Grøvik E, Tong E, Iv M, Emblem KE, Nilsen LB, Saxhaug C, Latysheva A, Jacobsen KD, Helland Å, Zaharchuk G, Rubin D (2021)
MRI pulse sequence integration for deep-learning-based brain metastases segmentation
Med Phys, 48 (10), 6020-6035
DOI 10.1002/mp.15136, PubMed 34405896

Publications 2020

Bangalore Yogananda CG, Shah BR, Vejdani-Jahromi M, Nalawade SS, Murugesan GK, Yu FF, Pinho MC, Wagner BC, Emblem KE, Bjørnerud A, Fei B, Madhuranthakam AJ, Maldjian JA (2020)
A Fully Automated Deep Learning Network for Brain Tumor Segmentation
Tomography, 6 (2), 186-193
DOI 10.18383/j.tom.2019.00026, PubMed 32548295

Clement P, Booth T, Borovečki F, Emblem KE, Figueiredo P, Hirschler L, Jančálek R, Keil VC, Maumet C, Özsunar Y, Pernet C, Petr J, Pinto J, Smits M, Warnert EAH (2020)
GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma
J Med Biol Eng, 41 (2), 115-125
DOI 10.1007/s40846-020-00582-z, PubMed 33293909

Digernes I, Nilsen LB, Grøvik E, Bjørnerud A, Løvland G, Vik-Mo E, Meling TR, Saxhaug C, Helland Å, Jacobsen KD, Geier O, Emblem KE (2020)
Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI
Phys Med Biol, 65 (22), 225020
DOI 10.1088/1361-6560/abb71a, PubMed 33200748

Fuster-Garcia E, Lorente Estellés D, Álvarez-Torres MDM, Juan-Albarracín J, Chelebian E, Rovira A, Acosta CA, Pineda J, Oleaga L, Mollá-Olmos E, Filice S, Due-Tønnessen P, Meling TR, Emblem KE, García-Gómez JM (2020)
MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas
Eur Radiol, 31 (3), 1738-1747
DOI 10.1007/s00330-020-07297-4, PubMed 33001310

Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT (2020)
Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients
Neurooncol Adv, 2 (1), vdaa157
DOI 10.1093/noajnl/vdaa157, PubMed 33392506

Hovden IT, Geier OM, Digernes I, Fuster-Garcia E, Løvland G, Vik-Mo E, Meling TR, Emblem KE (2020)
The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma
Eur J Radiol, 132, 109278
DOI 10.1016/j.ejrad.2020.109278, PubMed 33010685

Larsson C, Groote I, Vardal J, Kleppestø M, Odland A, Brandal P, Due-Tønnessen P, Holme SS, Hope TR, Meling TR, Fosse E, Emblem KE, Bjørnerud A (2020)
Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy
Magn Reson Imaging, 68, 106-112
DOI 10.1016/j.mri.2020.01.012, PubMed 32004711

Latysheva A, Geier OM, Hope TR, Brunetti M, Micci F, Vik-Mo EO, Emblem KE, Server A (2020)
Diagnostic utility of Restriction Spectrum Imaging in the characterization of the peritumoral brain zone in glioblastoma: Analysis of overall and progression-free survival
Eur J Radiol, 132, 109289
DOI 10.1016/j.ejrad.2020.109289, PubMed 33002815

Leone JP, Emblem KE, Weitz M, Gelman RS, Schneider BP, Freedman RA, Younger J, Pinho MC, Sorensen AG, Gerstner ER, Harris G, Krop IE, Morganstern D, Sohl J, Hu J, Kasparian E, Winer EP, Lin NU (2020)
Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases
Breast Cancer Res, 22 (1), 131
DOI 10.1186/s13058-020-01372-w, PubMed 33256829

Nilsen LB, Digernes I, Grøvik E, Saxhaug C, Latysheva A, Geier O, Breivik B, Sætre DO, Jacobsen KD, Helland Å, Emblem KE (2020)
Responses in the diffusivity and vascular function of the irradiated normal brain are seen up until 18 months following SRS of brain metastases
Neurooncol Adv, 2 (1), vdaa028
DOI 10.1093/noajnl/vdaa028, PubMed 32642687

van den Boomen M, Manhard MK, Snel GJH, Han S, Emblem KE, Slart RHJA, Sosnovik DE, Catana C, Rosen BR, Prakken NHJ, Nguyen CT, Borra RJH, Setsompop K (2020)
Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging
Radiology, 294 (3), 538-545
DOI 10.1148/radiol.2020191845, PubMed 31961241

Publications 2019

Del Mar Álvarez-Torres M, Juan-Albarracín J, Fuster-Garcia E, Bellvís-Bataller F, Lorente D, Reynés G, Font de Mora J, Aparici-Robles F, Botella C, Muñoz-Langa J, Faubel R, Asensio-Cuesta S, García-Ferrando GA, Chelebian E, Auger C, Pineda J, Rovira A, Oleaga L, Mollà-Olmos E, Revert AJ, Tshibanda L, Crisi G, Emblem KE, Martin D, Due-Tønnessen P et al. (2019)
Robust association between vascular habitats and patient prognosis in glioblastoma: An international multicenter study
J Magn Reson Imaging, 51 (5), 1478-1486
DOI 10.1002/jmri.26958, PubMed 31654541

Due-Tønnessen P, Pinho MC, Emblem KE, Hald JK, Kanoto M, Abildgaard A, Sederevicius D, Groote IR, Rapalino O, Bjørnerud A (2019)
The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma
Sci Rep, 9 (1), 19898
DOI 10.1038/s41598-019-56333-x, PubMed 31882644

Gerstner ER, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T (2019)
Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma
Clin Cancer Res, 26 (1), 206-212
DOI 10.1158/1078-0432.CCR-19-1739, PubMed 31558474

Latysheva A, Emblem KE, Brandal P, Vik-Mo EO, Pahnke J, Røysland K, Hald JK, Server A (2019)
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology, 61 (5), 545-555
DOI 10.1007/s00234-019-02173-5, PubMed 30712139

Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER (2019)
Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI
Sci Rep, 9 (1), 8721
DOI 10.1038/s41598-019-44365-2, PubMed 31197238

Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK (2019)
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium
Nat Biomed Eng, 3 (3), 230-245
DOI 10.1038/s41551-018-0334-7, PubMed 30948807

Publications 2018

Angeli S, Emblem KE, Due-Tonnessen P, Stylianopoulos T (2018)
Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI
Neuroimage Clin, 20, 664-673
DOI 10.1016/j.nicl.2018.08.032, PubMed 30211003

Digernes I, Grøvik E, Nilsen LB, Saxhaug C, Geier O, Reitan E, Sætre DO, Breivik B, Reese T, Jacobsen KD, Helland Å, Emblem KE (2018)
Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery
Adv Radiat Oncol, 3 (4), 559-567
DOI 10.1016/j.adro.2018.05.005, PubMed 30370356

Eide PK, Vatnehol SAS, Emblem KE, Ringstad G (2018)
Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes
Sci Rep, 8 (1), 7194
DOI 10.1038/s41598-018-25666-4, PubMed 29740121

Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK (2018)
Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III
J Comput Assist Tomogr, 42 (5), 807-815
DOI 10.1097/RCT.0000000000000742, PubMed 29901512

Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER (2018)
Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI
Sci Rep, 8 (1), 17062
DOI 10.1038/s41598-018-34820-x, PubMed 30459364

Meling TR, Latysheva A, Da Broi M, Jahr G, Holte H, Beiske K, Emblem KE (2018)
Is deep brain involvement in intracranial primary central nervous system lymphoma of importance for penetration of chemotherapeutic agents?
Neuroradiology, 60 (7), 703-713
DOI 10.1007/s00234-018-2038-9, PubMed 29804159

Ringstad G, Valnes LM, Dale AM, Pripp AH, Vatnehol SS, Emblem KE, Mardal KA, Eide PK (2018)
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
JCI Insight, 3 (13)
DOI 10.1172/jci.insight.121537, PubMed 29997300

Publications 2017

Andronesi OC, Esmaeili M, Borra RJH, Emblem K, Gerstner ER, Pinho MC, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Ivy SP, Wen PY, Duda DG, Jain R, Rosen BR, Sorensen GA, Batchelor TT (2017)
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival
NPJ Precis Oncol, 1
DOI 10.1038/s41698-017-0020-3, PubMed 29202103

Digernes I, Bjørnerud A, Vatnehol SAS, Løvland G, Courivaud F, Vik-Mo E, Meling TR, Emblem KE (2017)
A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI
J Cereb Blood Flow Metab, 37 (6), 2237-2248
DOI 10.1177/0271678X17694187, PubMed 28273722

Ringstad G, Lindstrøm EK, Vatnehol SAS, Mardal KA, Emblem KE, Eide PK (2017)
Non-invasive assessment of pulsatile intracranial pressure with phase-contrast magnetic resonance imaging
PLoS One, 12 (11), e0188896
DOI 10.1371/journal.pone.0188896, PubMed 29190788

Publications 2016

Emblem KE, Jain RK (2016)
Improving treatment of liver metastases by targeting nonangiogenic mechanisms
Nat Med, 22 (11), 1209-1210
DOI 10.1038/nm.4228, PubMed 27824818

Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, Jain RK, Batchelor TT, Gerstner ER (2016)
Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma
J Neurooncol, 131 (3), 603-610
DOI 10.1007/s11060-016-2332-5, PubMed 27853960

Publications 2015

Gerstner ER, Emblem KE, Sorensen GA (2015)
Vascular Magnetic Resonance Imaging in Brain Tumors During Antiangiogenic Therapy--Are We There Yet?
Cancer J, 21 (4), 337-42
DOI 10.1097/PPO.0000000000000128, PubMed 26222087

Heck A, Emblem KE, Casar-Borota O, Bollerslev J, Ringstad G (2015)
Quantitative analyses of T2-weighted MRI as a potential marker for response to somatostatin analogs in newly diagnosed acromegaly
Endocrine, 52 (2), 333-43
DOI 10.1007/s12020-015-0766-8, PubMed 26475495

Heck A, Emblem KE, Casar-Borota O, Ringstad G, Bollerslev J (2015)
MRI T2 characteristics in somatotroph adenomas following somatostatin analog treatment in acromegaly
Endocrine, 53 (1), 327-30
DOI 10.1007/s12020-015-0816-2, PubMed 26615593

Jafari-Khouzani K, Emblem KE, Kalpathy-Cramer J, Bjørnerud A, Vangel MG, Gerstner ER, Schmainda KM, Paynabar K, Wu O, Wen PY, Batchelor T, Rosen B, Stufflebeam SM (2015)
Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients
Transl Oncol, 8 (3), 137-46
DOI 10.1016/j.tranon.2015.03.002, PubMed 26055170

Juuhl-Langseth M, Hartberg CB, Holmén A, Thormodsen R, Groote IR, Rimol LM, Emblem KE, Agartz I, Rund BR (2015)
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders
PLoS One, 10 (7), e0130435
DOI 10.1371/journal.pone.0130435, PubMed 26230626

Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK (2015)
Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma
J Clin Oncol, 33 (10), 1197-213
DOI 10.1200/JCO.2014.55.9575, PubMed 25713439

Ringstad G, Emblem KE, Eide PK (2015)
Phase-contrast magnetic resonance imaging reveals net retrograde aqueductal flow in idiopathic normal pressure hydrocephalus
J Neurosurg, 124 (6), 1850-7
DOI 10.3171/2015.6.JNS15496, PubMed 26636385

Ringstad G, Emblem KE, Geier O, Alperin N, Eide PK (2015)
Aqueductal Stroke Volume: Comparisons with Intracranial Pressure Scores in Idiopathic Normal Pressure Hydrocephalus
AJNR Am J Neuroradiol, 36 (9), 1623-30
DOI 10.3174/ajnr.A4340, PubMed 25977480

Ringstad G, Emblem KE, Geier O, Alperin N, Eide PK (2015)
Reply: To PMID 25977480
AJNR Am J Neuroradiol, 36 (9), 1633-4
DOI 10.3174/ajnr.A4488, PubMed 26251437

Publications 2014

Brabrand K, de Lange C, Emblem KE, Reinholt FP, Saugstad OD, Stokke ES, Munkeby BH (2014)
Contrast-enhanced ultrasound identifies reduced overall and regional renal perfusion during global hypoxia in piglets
Invest Radiol, 49 (8), 540-6
DOI 10.1097/RLI.0000000000000053, PubMed 24637585

Due-Tonnessen P, Rasmussen I, Berntsen EM, Bjornerud A, Emblem KE (2014)
Identifying the central sulcus in patients with intra-axial lesions: a multicenter study comparing conventional presurgical MRI to topographical analysis and BOLD-fMRI
J Comput Assist Tomogr, 38 (1), 1-8
DOI 10.1097/RCT.0b013e3182a589e0, PubMed 24378889

Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK (2014)
Vessel caliber--a potential MRI biomarker of tumour response in clinical trials
Nat Rev Clin Oncol, 11 (10), 566-84
DOI 10.1038/nrclinonc.2014.126, PubMed 25113840

Emblem KE, Pinho MC, Zöllner FG, Due-Tonnessen P, Hald JK, Schad LR, Meling TR, Rapalino O, Bjornerud A (2014)
A generic support vector machine model for preoperative glioma survival associations
Radiology, 275 (1), 228-34
DOI 10.1148/radiol.14140770, PubMed 25486589

Kalpathy-Cramer J, Gerstner ER, Emblem KE, Andronesi O, Rosen B (2014)
Advanced magnetic resonance imaging of the physical processes in human glioblastoma
Cancer Res, 74 (17), 4622-4637
DOI 10.1158/0008-5472.CAN-14-0383, PubMed 25183787

Publications 2013

Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK (2013)
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
Proc Natl Acad Sci U S A, 110 (47), 19059-64
DOI 10.1073/pnas.1318022110, PubMed 24190997

Emblem KE, Due-Tonnessen P, Hald JK, Bjornerud A, Pinho MC, Scheie D, Schad LR, Meling TR, Zoellner FG (2013)
Machine learning in preoperative glioma MRI: survival associations by perfusion-based support vector machine outperforms traditional MRI
J Magn Reson Imaging, 40 (1), 47-54
DOI 10.1002/jmri.24390, PubMed 24753371

Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG (2013)
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy
Nat Med, 19 (9), 1178-83
DOI 10.1038/nm.3289, PubMed 23955713

Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER (2013)
Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation
Oncologist, 19 (1), 75-81
DOI 10.1634/theoncologist.2013-0101, PubMed 24309981

Thormodsen R, Rimol LM, Tamnes CK, Juuhl-Langseth M, Holmén A, Emblem KE, Rund BR, Agartz I (2013)
Age-related cortical thickness differences in adolescents with early-onset schizophrenia compared with healthy adolescents
Psychiatry Res, 214 (3), 190-6
DOI 10.1016/j.pscychresns.2013.07.003, PubMed 24144503

Publications 2012

Juuhl-Langseth M, Rimol LM, Rasmussen IA, Thormodsen R, Holmén A, Emblem KE, Due-Tønnessen P, Rund BR, Agartz I (2012)
Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities
Psychiatry Res, 203 (1), 14-23
DOI 10.1016/j.pscychresns.2011.10.005, PubMed 22917502

Zöllner FG, Emblem KE, Schad LR (2012)
SVM-based glioma grading: Optimization by feature reduction analysis
Z Med Phys, 22 (3), 205-14
DOI 10.1016/j.zemedi.2012.03.007, PubMed 22503911

Publications 2011

Bjornerud A, Sorensen AG, Mouridsen K, Emblem KE (2011)
T1- and T2*-dominant extravasation correction in DSC-MRI: part I--theoretical considerations and implications for assessment of tumor hemodynamic properties
J Cereb Blood Flow Metab, 31 (10), 2041-53
DOI 10.1038/jcbfm.2011.52, PubMed 21505483

de Lange C, Brabrand K, Emblem KE, Bjornerud A, Løberg EM, Saugstad OD, Munkeby BH (2011)
Cerebral perfusion in perinatal hypoxia and resuscitation assessed by transcranial contrast-enhanced ultrasound and 3 T MRI in newborn pigs
Invest Radiol, 46 (11), 686-96
DOI 10.1097/RLI.0b013e3182266431, PubMed 21730873

Emblem KE, Bjornerud A, Mouridsen K, Borra RJ, Batchelor TT, Jain RK, Sorensen AG (2011)
T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients
J Cereb Blood Flow Metab, 31 (10), 2054-64
DOI 10.1038/jcbfm.2011.39, PubMed 21505476

Garzón B, Emblem KE, Mouridsen K, Nedregaard B, Due-Tønnessen P, Nome T, Hald JK, Bjørnerud A, Håberg AK, Kvinnsland Y (2011)
Multiparametric analysis of magnetic resonance images for glioma grading and patient survival time prediction
Acta Radiol, 52 (9), 1052-60
DOI 10.1258/ar.2011.100510, PubMed 21969702

Ringstad GA, Emblem KE, Holland D, Dale AM, Bjornerud A, Hald JK (2011)
Assessment of pituitary adenoma volumetric change using longitudinal MR image registration
Neuroradiology, 54 (5), 435-43
DOI 10.1007/s00234-011-0894-7, PubMed 21647587

Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, Wang M, Wen PY, Ivy P, Batchelor TT, Jain RK (2011)
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
Cancer Res, 72 (2), 402-7
DOI 10.1158/0008-5472.CAN-11-2464, PubMed 22127927

Thormodsen R, Jensen J, Holmèn A, Juuhl-Langseth M, Emblem KE, Andreassen OA, Rund BR (2011)
Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: an fMRI study
Psychiatry Res, 194 (3), 257-262
DOI 10.1016/j.pscychresns.2011.05.011, PubMed 22079661

Publications 2010

Bjørnerud A, Emblem KE (2010)
A fully automated method for quantitative cerebral hemodynamic analysis using DSC-MRI
J Cereb Blood Flow Metab, 30 (5), 1066-78
DOI 10.1038/jcbfm.2010.4, PubMed 20087370

Zöllner FG, Emblem KE, Schad LR (2010)
Support vector machines in DSC-based glioma imaging: suggestions for optimal characterization
Magn Reson Med, 64 (4), 1230-6
DOI 10.1002/mrm.22495, PubMed 20564592

Publications 2009

Emblem KE (2009)
Combined structural, microvascular and functional mappingof brain tumors for improved diagnosis and treatment planning
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 793, 1 b. (flere pag.)
BIBSYS 092931421, ISBN 978-82-8072-795-4

Emblem KE, Bjornerud A (2009)
An automatic procedure for normalization of cerebral blood volume maps in dynamic susceptibility contrast-based glioma imaging
AJNR Am J Neuroradiol, 30 (10), 1929-32
DOI 10.3174/ajnr.A1680, PubMed 19628627

Emblem KE, Due-Tonnessen P, Hald JK, Bjornerud A (2009)
Automatic vessel removal in gliomas from dynamic susceptibility contrast imaging
Magn Reson Med, 61 (5), 1210-7
DOI 10.1002/mrm.21944, PubMed 19253390

Emblem KE, Nedregaard B, Hald JK, Nome T, Due-Tonnessen P, Bjornerud A (2009)
Automatic glioma characterization from dynamic susceptibility contrast imaging: brain tumor segmentation using knowledge-based fuzzy clustering
J Magn Reson Imaging, 30 (1), 1-10
DOI 10.1002/jmri.21815, PubMed 19557840

Publications 2008

Emblem KE, Nedregaard B, Nome T, Due-Tonnessen P, Hald JK, Scheie D, Borota OC, Cvancarova M, Bjornerud A (2008)
Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume maps
Radiology, 247 (3), 808-17
DOI 10.1148/radiol.2473070571, PubMed 18487536

Emblem KE, Scheie D, Due-Tonnessen P, Nedregaard B, Nome T, Hald JK, Beiske K, Meling TR, Bjornerud A (2008)
Histogram analysis of MR imaging-derived cerebral blood volume maps: combined glioma grading and identification of low-grade oligodendroglial subtypes
AJNR Am J Neuroradiol, 29 (9), 1664-70
DOI 10.3174/ajnr.A1182, PubMed 18583405

Emblem KE, Zoellner FG, Tennoe B, Nedregaard B, Nome T, Due-Tonnessen P, Hald JK, Scheie D, Bjornerud A (2008)
Predictive modeling in glioma grading from MR perfusion images using support vector machines
Magn Reson Med, 60 (4), 945-52
DOI 10.1002/mrm.21736, PubMed 18816815

Munkeby BH, De Lange C, Emblem KE, Bjørnerud A, Kro GA, Andresen J, Winther-Larssen EH, Løberg EM, Hald JK (2008)
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging
Acta Radiol, 49 (9), 1049-57
DOI 10.1080/02841850802334224, PubMed 18720081

Publications 1998

Emblem K (1998)
Side notes on negative consequences and uncertainty
TECH RISK S, 12, 124-125